Physiological, Sensory and Ergogenic Effects of Salbutamol - Implications for Athletic Screening and β2 Agonist Use in Sport
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- Difference in time to exhaustion following salbutamol inhalation compared to placebo inhalation.
研究概览
简要总结
β2-Agonists, commonly used to treat asthma, have also been used by athletes to enhance performance, leading to their ban by the International Olympic Committee in 1972. Research has shown non-asthmatics receive no benefit from these drugs at therapeutic dosages; however, many elite athletes still use them, and asthmatic athletes often win more Olympic medals. In some non-asthmatics, β2-agonists may improve breathing limitations during high intensity exercise, which may improve performance. Therefore, we aim to examine if there is a select group of non-asthmatic individuals who experience breathing limitations that may receive benefit from β2-agonists.
详细描述
Purpose:
The purpose of this study is to examine the effects of β2-agonists on exercise performance in non-asthmatic male and female endurance athletes.
Hypothesis:
Our primary hypothesis is that ß2-agonists will improve exercise duration to a greater degree in athletes who experience expiratory flow limitation (EFL) compared to those who do not experience EFL. Additionally, female athletes will, on average, experience greater benefits with ß2-agonists due to a greater prevalence of EFL than males.
Justification:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aerobic capacity (V̇O2max) greater than 120% predicted
- •Body mass index (BMI) > 18 and < 30 kg/m2
- •Ability to read and understand English
- •Currently training and/or competing in endurance sports (i.e. running or cycling)
排除标准
- •Smoking history or currently smoking. Currently smoking is defined as regular use of cigarettes or cannabis at any point in the past year. History of smoking is defined as smoking more than 1 pack year for cigarettes or the equivalent in cannabis use measured as puffs per day / 200 (number of puffs in a pack of cigarettes).
- •Use of cannabis within the past 30 days or has a smoking history of at least 1 pack year.
- •Use of vaping devices or e-cigarettes in the past 30 days, or has used them more than 10 times in their lifetime.
- •History or current symptoms of cardiopulmonary disease (excluding controlled asthma)
- •Contraindications to exercise testing defined as anything that would prevent exercise under proper and safe conditions (e.g., a problem with the heart or lungs, muscle)
- •Neuromuscular or musculoskeletal condition
研究组 & 干预措施
Salbutamol inhaler
Participants will take four inhalations of salbutamol, with 60 seconds between each inhalation, totaling a therapeutic dose of 400µg of salbutamol prior to performing an incremental cardiopulmonary exercise test.
干预措施: Salbutamol (Drug)
Placebo inhaler
Participants will take four inhalations of placebo, with 60 seconds between each inhalation, prior to performing an incremental cardiopulmonary exercise test.
干预措施: Placebo (Drug)
结局指标
主要结局
Difference in time to exhaustion following salbutamol inhalation compared to placebo inhalation.
时间窗: Up to 2 weeks
Exercise duration will be measured during a time to exhaustion cardiopulmonary exercise test on a stationary cycle ergometer or treadmill.
Sex differences in time to exhaustion following salbutamol inhalation
时间窗: Up to 2 weeks
Exercise duration will be measured during a time to exhaustion cardiopulmonary exercise test on a stationary cycle ergometer or treadmill. Sexes will be compared within modality.
次要结局
- To examine the effects of salbutamol on expiratory flow limitation in endurance athletes(Up to 2 weeks)
- To explore sex differences in dyspnea following salbutamol inhalation.(Up to 2 weeks)
- To examine ventilatory responses of male and female endurance athletes to exercise with salbutamol.(Up to 2 weeks)
- To explore the effects of salbutamol on exercise duration and expiratory flow limitation in both asthmatic and non-asthmatic individuals.(Up to 2 weeks)
研究者
Jordan Guenette
Professor
University of British Columbia