Effect of Pain Control on the Diagnosis of Acute Appendicitis on the Diagnostic Accuracy of General Surgeon

Phase 4

Completed

• Conditions: Appendicitis
• Interventions: Drug: Morphine

• Registration Number: NCT00783016
• Lead Sponsor: Seoul National University Hospital

Brief Summary

The pain control in surgical abdomen has been in debate in masking the correct diagnosis. We would like to investigate the effect of pain control on the diagnostic accuracy of surgeon in suspicious appendicitis patients.

We would give morphine or placebo to the patients suspected of appendicitis randomly and in double-blinded manner, and then surgeons would exam the patient and give the impression for the possibility of the appendicitis(grading 1 to 4).

With this grading, we compare these impression between two groups.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-10
• Study First Submitted: 2008-10-30
• Study First Submitted QC: 2008-10-30
• Study First Posted: 2008-10-31
• Primary Completion: 2011-02
• Study Completion: 2011-05
• Status Verified: 2011-07
• Last Update Submitted: 2011-07-25
• Last Update Posted: 2011-07-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 234

Inclusion Criteria

• the patients suspected of acute appendicitis over 15 years

Exclusion Criteria

• less than 15 years
• pregnant
• allergic to morphine
• systolic blood pressure<100mmHg
• received pain killer prior to ED visit
• do not consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Morphine	Morphine	-
Placebo	Morphine	-

Primary Outcome Measures

Name	Time	Method
AUC of ROC of the impression of diagnosis for the appendicitis by surgeon

Trial Locations

Locations (1)

Seoul National University Bundang Hospital, Emergency room; 🇰🇷 Seongnam-si, Gyeonggi-do, Korea, Republic of