Survival Significance and Clinical Characteristics of Molecular Pathology and Genetic Variation in Brain Gliomas
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 3,000
- 试验地点
- 1
- 主要终点
- Overall Survival (OS)
研究概览
简要总结
This study aims to collect clinical, radiological, pathological, molecular and genetic data including detailed clinical parameters, MR and histopathology images, molecular pathology and genetic data. This study seeks to find the prognostic and clinical significance based on molecular and genetic biomarkers/subgroups of gliomas.
详细描述
Precise classification based on molecular and genetic biomarkers/subgroups for gliomas is challenging. This study aims to collect clinical, radiological, pathological, molecular and genetic data including detailed clinical parameters, MR and histopathology images, molecular pathology (1p/19q co-deletion, MGMT methylation, IDH and TERTp mutations, etc) and genetic data (Whole exome sequencing, RNA sequencing, proteomics, etc). This study seeks to find the prognostic and clinical significance based on molecular and genetic biomarkers/subgroups of gliomas.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 1 Year 至 95 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients must have radiologically and histologically confirmed diagnosis of primary glioma
- •Life expectancy of greater than 3 months
- •Must receive tumor resection
- •Must have sufficient fresh frozen tissues for NGS
- •Signed informed consent
排除标准
- •No gliomas
- •No sufficient amount of tumor tissues for detection of molecular pathology
- •Patients who are pregnant or breast feeding
- •Patients who are suffered from severe systematic malfunctions
- •Do not have sufficient fresh frozen tissues for NGS
结局指标
主要结局
Overall Survival (OS)
时间窗: From enrollment to death of patients. Estimated about 5 years.
The length of time from enrollment until the time of death (OS, overall survival)
次要结局
未报告次要终点
研究者
Zhenyu Zhang
Doctor
The First Affiliated Hospital of Zhengzhou University