The Impact of Premorbid Illnesses on the Risk of ICU Admission and Short-term Outcome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 9,905
- 试验地点
- 1
- 主要终点
- Risk factors of ICU mortality COVID-19/ARDS
研究概览
简要总结
The Corona virus disease 2019 (COVID-19) pandemic is currently involving all parts of the world. Several risk factors for critical illness and death from the disease have been proposed. However, it is still unclear if the observed associations between different comorbidities and chronic medications and severe COVID-19 disease and mortality is different from associations between the same factors and other severe diseases requiring intensive care unit (ICU) -care. This is important since some of the observed risk factors are very common in the aged who, by age alone, are more prone to a more severe course of any disease. By combining several registries, this study will compare, on several comorbidities such as hypertension and diabetes , the first 2000 cases of COVID-19 patients receiving critical care in Sweden to a Swedish sepsis-cohort and a Swedish adult respiratory distress syndrome (ARDS) -cohort.
详细描述
The Corona virus disease 2019 (COVID-19) pandemic is currently involving all parts of the world. Several risk factors for critical illness and death from the disease have been proposed. However, it is still unclear if the observed associations between different comorbidities and chronic medications and severe COVID-19 disease and mortality is different from associations between the same factors and other severe diseases requiring ICU-care. This is important since some of the observed risk factors are very common in the aged who, by age alone, are more prone to a more severe course of any disease. By combining several registries, this study will compare, on several comorbidities such as hypertension and diabetes , the first 2000 cases of COVID-19 patients receiving critical care in Sweden to a Swedish sepsis-cohort and a Swedish ARDS-cohort.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •° Individual registered in the Swedish intensive care registry (SIR) with COVID-19 Before 27 May
- •Individual registered in the SIR with Severe sepsis or septic chock 2011-
- •Individual registered in the SIR with ARDS 2011-2016.
排除标准
- •Age below 18 years
- •Individual registered in the Swedish intensive care registry without a personal identification number
结局指标
主要结局
Risk factors of ICU mortality COVID-19/ARDS
时间窗: Five years preceding ICU admission to ICU discharge
In a Cox proportional hazards model with the outcome ICU-mortality the HR for the interaction between several comorbidities and a binary variable COVID-19/ARDS are determined.
Risk factors of ICU care COVID-19/Sepsis
时间窗: Five years preceding ICU admission to ICU admission
In a binary logistics model with the outcome Sepsis or COVID-19 the OR for several comorbidities are determined.
Risk factors of ICU mortality COVID-19/Sepsis
时间窗: Five years preceding ICU admission to ICU discharge
In a Cox proportional hazards model with the outcome ICU-mortality the hazard ratio (HR) for the interaction between several comorbidities and a binary variable COVID-19/Sepsis are determined.
Risk factors of ICU care COVID-19/ARDS
时间窗: Five years preceding ICU admission to ICU admission
In a binary logistics model with the outcome ARDS or COVID-19 the OR for several comorbidities are determined.
次要结局
未报告次要终点