Attention Bias Modification Treatment for Major Depressive Disorder in Adolescents
- Conditions
- Major Depressive Disorder, Single Episode, Unspecified
- Interventions
- Behavioral: ABMT
- Registration Number
- NCT02078258
- Lead Sponsor
- Hunan Normal University
- Brief Summary
In this study, we test whether a two-week 8-session neutral attention bias modification (ABM) training and a two-week 4-session positive ABM could reduce depressive symptoms relative to placebo controls in adolescents with major depressive disorder at posttraining and follow-ups during one year.
- Detailed Description
Depression is a common health problem in adolescents. Negative attentional bias has been theorized to play a critical role in the onset and maintenance of depression, suggesting that reduction of such biases may treat symptoms of depression. Recent studies have shown that attention bias modification(ABM) training could reduce depressive symptoms in both dysphoria and previously depressed adult patients.To test the effectiveness of ABM training on the treatment of depressive symptoms in depressed adolescents, we designed a randomized, double-blind, placebo controlled trial in adolescents with major depressive disorder(MDD).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 45
- Meet the major depression disorder's criteria
- bipolar disorder, schizophrenia or organic mental disorder;
- any concurrent psychotherapy;
- any concurrent psychotropic medication.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo control ABMT The placebo ABMT was identical to the active ABMT, but shifted toward neutral (50%) or sad (50%) stimuli equally often (i.e., 50/50 training). Attentional bias modification training ABMT Attention bias modification training (ABMT) is a a variation of attention tasks to modify attentional biases, in which a probe always appears in the location of relatively positive stimuli after the two stimuli, one neutral and one emotional, were simultaneously presented. Participants complete 8 sessions (320 trials each with 20 minutes) over two weeks of neutral ABMT to shift attention toward neutral, in which a probe appeared in the location of neutral with 90% probability, and sadness-related with 10% probality. At a 9-week follow-up, participants completed 4 more sessions (480 trials each with 30 minutes)over two weeks of positive ABMT to shift attention toward positive words,in which a probe appeared in the location of 67% positive or 33% neutral.
- Primary Outcome Measures
Name Time Method Changes in depressive symptom number baseline, 7-week, 6-month follow-up Depressive symptom accounts measured by Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children.
Changes in depressive severity baseline, 7-week, 6-month follow-up depressive severity measured by the construct interview of the Schedule for Affective Disorders and Schizophrenia for School-Age Children(K-SADS)
- Secondary Outcome Measures
Name Time Method Diagnostic status of major depressive disorder baseline, 7-week, 6-month follow-up Assessed by the diagnostic interview of the Schedule for Affective Disorders and Schizophrenia for School-Age Children
Change of Self-report symptoms baseline, 7-week, 6-, 12-month follow-up symptoms measured by the Center for Epidemiological Studies Depression Scale (CES-D), State-Trait Anxiety Inventory-Trait(STAI-T)，Rumination Response Style（RRS)，Suicidal Ideation Questionnaire（SIQ）
Trial Locations
- Locations (1)
Department of Psychology, Hunan Normal University
🇨🇳Changsha, Hunan, China