Blood Flow Index as an Indicator of Successful Peripheral Nerve Block

Completed

• Conditions: Laser

• Registration Number: NCT03169517
• Lead Sponsor: Huazhong University of Science and Technology

Brief Summary

Laser speckle contrast imaging (LSCI) allows real-time, non-invasive, quantitative measurements of regional blood flow. The aim of this prospective observational study was to evaluate the blood flow changes by LSCI after peripheral nerve block and determine whether this novel optical technique can be used as a reliable indicator of successful blocks.

Detailed Description

Methods: One hundred adult patients scheduled for elective upper or lower limb surgery with peripheral nerve block will receive LSCI measurements and pinprick sensory tests before the block and at 5-min intervals till 30 min after the block. The sensitivity, specificity of LSCI as a diagnostic method will be determined by receiver operator characteristic analysis.

Clinical Implications: LSCI with quantitative data could be used as an indicator of successful blocks.

Study Timeline

• Study First Submitted: 2017-05-24
• Study First Submitted QC: 2017-05-25
• Study Start: 2017-05-27
• Study First Posted: 2017-05-30
• Status Verified: 2017-09
• Primary Completion: 2017-09-04
• Study Completion: 2017-09-04
• Last Update Submitted: 2017-09-04
• Last Update Posted: 2017-09-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

• informed consent
• American Society of Anesthesiologists physical statusⅠ-Ⅱ
• Undergo elective upper or lower limb surgery with peripheral nerve block

Exclusion Criteria

• refusal to participate in the study
• peripheral vascular disease
• digit injury or deficiency
• colored or infected fingernails/toenails
• BMI>35
• those who had taken vasodilatory drugs before surgery
• preoperative analgesic medications
• Any contraindications to peripheral nerve block such as coagulation abnormalities, allergy to local anaesthetics, peripheral neuropathy.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
diagnostic power of LSCI and pinprick sensory tests for predicting successful and failed blocks	at 5-min intervals till 30 min after regional block	sensitivity and specificity

Secondary Outcome Measures

Name	Time	Method
blood flow index	5 min before regional block and at 5-min intervals till 30 min after regional block	perfusion unit(PU)

Trial Locations

Locations (1)

Tongji Hospital; 🇨🇳 Wuhan, Hubei, China