Choroidal Blood Flow in Acute and Chronic Central Serous Chorioretinopathy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Change in mean blur rate
研究概览
简要总结
Patients with central serous chorioretinopathy (CSC) will be monitored with laser speckle flow graphy (LSFG), swept source optical coherence tomography (SS-OCT) and SS-OCT angiography (SS-OCTA). The aim is to unveil the flow and pulse wave characteristics of the choroidal circulation in acute CSC and chronic CSC.
详细描述
Acute CSC - The proposed study tests the hypothesis that choroidal blood flow characteristics are related to the eventual resolution of subretinal fluid. Such relation can shed light on pathophysiological disease mechanisms and constitute a biomarker for disease activity.
Chronic CSC - The proposed study tests the hypothesis that choroidal blood flow characteristics will change in response to standard treatment with PDT. The research of such changes will increase the understanding of the treatment response. This knowledge will help in the effort to understand the why some patients are non-responsive to the treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Able to sign informed consent
- •Possible to obtain fundus imaging
- •Acute CSC ˂4 months of duration in one eye, defined as:
- •Subfoveal presence of SRF on OCT
- •Present attack is 1st -3rd attack of CSC
- •b) Patient history and examination consistent with acute CSC c) Characteristic appearance of acute CSC on fundus autofluorescence (FAF) and OCT
- •Chronic CSC ≥4 months of duration in one eye, defined as:
- •Subfoveal presence of SRF on OCT
- •Subjective visual loss/symptoms
- •Characteristic appearance of chronic CSC on FAF, fluorescein angiography (FA), and indocyanin angiography (ICGA) and OCT
- •Patient history and examination consistent with chronic CSC
排除标准
- •History of retinal disease other than CSC (e.g. retinal detachment)
- •Contraindications for FA, ICGA or PDT (only for chronic CSC)
研究组 & 干预措施
Chronic
Patients with chronic CSC, i.e. symptoms and SRF for more than 4 months.
干预措施: Verteporfin (Drug)
结局指标
主要结局
Change in mean blur rate
时间窗: 6 months
Relative changes in choroidal blood flow
Change in pulse wave form analysis
时间窗: 6 months
Changes in the shapes of pulse curves
次要结局
- Change in choroidal density(6 months)
- Change in choroidal thickness(6 months)