Urine Interleukin-37 as a Biomarker of Mortality Risk in Patients With Sepsis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 99
- 试验地点
- 1
- 主要终点
- 28-day all-cause mortality
研究概览
简要总结
This study aims to evaluate the efficacy of IL-37 as a biomarker to predict mortality risk in adults with sepsis.
详细描述
Sepsis patients admitted in the Department of Critical Care Medicine, Zhongnan Hospital will be included.
There are three groups of patients in this study: control group, sepsis group and septic shock group.
The interleukin-37 (IL-37) concentration in urine was analyzed in the day 1, 2, 4, 6.
Additionally, IL-37 concentration between blood stream infection groups and non-infection groups were analyzed. IL-37 concentration between survivors and non-survivors were also compared. IL-37 concentration were followed from day 1, 2, 4, 6.The correlation between the concentration of IL-37, IL-1β, IL-6、IL-10 and TNF-α were analyzed. Furthermore, the investigators will determine the correlation between the concentration of IL-37, sepsis associated organ dysfunction, 28-day mortality. Lastly, the predictive value of IL-37 to sepsis associated organ dysfunction and prognosis were explored.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18 years or older
- •Expected length of stay>24 hours in intensive care unit (ICU)
- •Sequential organ failure assessment (SOFA) score ≥ 2 on ICU admission with a suspicion of infection
排除标准
- •ICU readmission in 28 days
结局指标
主要结局
28-day all-cause mortality
时间窗: 28 day
Number of patients who were confirmed to be dead within 28-day from enrollment onto the study
次要结局
- Hospital length of stay(28day)
- ICU all-cause mortality(28 day)
- ICU length of stay(28 day)