Kidney Function in Diabetics During CPB (Cardio Pulmonary Bypass)

Suspended

• Conditions: Diabetes Mellitus, Kidney, CPB

• Registration Number: NCT03405532
• Lead Sponsor: Sahlgrenska University Hospital, Sweden

Brief Summary

Filtration of urine in the kidney requires sufficient oxygen supply. The filtration of urine is greater in patents with diabetes. Our theory is that the diabetic kidney has a higher oxygen demand than the non diabetic kidney thereby making the diabetic kidney more sensitive to decreased oxygen delivery following reduced blood flow. With a catheter inserted into the kidney vein we will monitor the blood flow and oxygen saturation before and during CPB, in patient with diabetes.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-01-05
• Study Start: 2018-01-11
• Study First Submitted QC: 2018-01-19
• Study First Posted: 2018-01-23
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-21
• Last Update Posted: 2024-04-23
• Primary Completion: 2030-01
• Study Completion: 2030-01

Recruitment & Eligibility

• Status: SUSPENDED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients with diabetes mellitus
• Serum creatinine < 150 micromol/L preoperative
• Heart surgery requiring CPB
• LV (left ventricle) EF >40 %
• Normal hemoglobin

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Renal O2 extraction	2 years	Renal O2 extraction measured by sampling blood from a catheter inserted into the kidney vein.

Secondary Outcome Measures

Name	Time	Method
GFR	2 years	GFR (Glomerular filtration rate), measured with CrEDTA- and PAH- clearance.
Renal blood flow	2 years	Change in renal blood flow measured by sampling blood from a catheter inserted into the kidney vein

Trial Locations

Locations (1)

Sahlgrenska University Hospital; 🇸🇪 Gothenburg, Sweden