Nasopharyngeal Carcinoma Screening in Zhongshan City

Active, not recruiting

• Conditions: Nasopharyngeal Carcinoma

• Registration Number: NCT02501993
• Lead Sponsor: Zhongshan People's Hospital, Guangdong, China

Brief Summary

The primary objective is to determine the early diagnosis rate and mortality rate of the Nasopharyngeal Carcinoma (NPC) in the study population.

The secondary objective is to determine the incidence of NPC in the study population.

Detailed Description

The research is to evaluate the effect of NPC screening, also as an extended study of Screening for Nasopharyngeal Carcinoma in High Risk Populations (NCT00941538).

The program was conducted in Xiaolan and Minzhong towns of Zhongshan city in 2012.

All participants will be tested for anti-EBV antibody by using serum samples. Participants are stratified into those having high, moderate and low antibody levels, those having moderate antibody levels are invited to retest annually in the following 3 years and those found to have high antibody levels on these occasions are referred to centers for diagnostic workup for NPC.

Study Timeline

• Study Start: 2012-03
• Study First Submitted: 2015-07-13
• Study First Submitted QC: 2015-07-15
• Study First Posted: 2015-07-17
• Primary Completion: 2019-12
• Status Verified: 2023-07
• Last Update Submitted: 2023-07-12
• Last Update Posted: 2023-07-13
• Study Completion: 2023-12

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 25000

Inclusion Criteria

• Subject residents in Zhongshan city
• Subject is 30 to 59 years of age inclusive
• Subject has no medical record of nasopharyngeal carcinoma
• ECOG 0-2
• Subject has psychical condition and well consciousness
• Subject is able to comprehend, sign, and date the written informed consent document to participate in the study.

Exclusion Criteria

• Subject has heavy cardiovascular, liver or kidney disease
• Subject has medical record of nasopharyngeal carcinoma
• Subject who is not residing in Zhongshan City

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The early detection rate (stage I and II) of Nasopharyngeal Carcinoma	10 years
The mortality rate of Nasopharyngeal Carcinoma	10 years

Secondary Outcome Measures

Name	Time	Method
The incidence of Nasopharyngeal Carcinoma	10 years

Trial Locations

Locations (1)

Zhongshan People's Hospital; 🇨🇳 Zhongshan, Guangdong, China