Effects of oral coenzyme Q10 supplementation and ischemic preconditioning on tourniquet-induced ischemia and reperfusion injury in unilateral total knee arthroplasty

Phase 1

Recruiting

• Conditions: knee osteoarthritisknee arthroplastyischemia and reperfusion injury; knee arthroplasty; coenzyme q10; ischemic preconditioning

• Registration Number: TCTR20190128001
• Lead Sponsor: /A

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-01-28
• Study Completion: 2020-01-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Osteoarthritis of knee joint patients with ASA classification I-III who are scheduled for elective unilateral total knee arthoplasty

Exclusion Criteria

1. Body mass index ≤ 35 kg/m2
2. Presentation of any conditions that may interfere the oxidative stress levels including any malignant diseases, any infectious diseases, neurodegenerative diseases, atherosclerotic disease, peripheral arterial disease, chronic kidney disease and active heavy smoking
3. Antioxidant use within 4 weeks
4. Glucocorticoid use within 3 months
5. Presentation of contraindications of regional anesthesia including coagulopathy and increased intracranial pressure
6. Allergy to any medications in the study protocol
7. Presentation of any conditions that may interfere clinical assessment including preoperative immobility, preoperative delirium or cognitive dysfunction
8. Perioperative blood transfusion

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mitochondrial oxygen consumption 2 wk before surgery, 30 min of TQ inflation, 120 min and 1 day after TQ release, 2 wk after surgery Measure mitochondrial function of peripheral blood mononuclear cells isolated from blood sample