The Effect of Vitamin K2 on Bone Turnover

Phase 4

Completed

• Conditions: Osteoporosis

• Registration Number: NCT00548509
• Lead Sponsor: Eisai Limited

Brief Summary

To investigate the effect of menatetrenone on bone turnover in postmenopausal patients with osteoporosis. One month of menatetrenone therapy enhanced the secretion and gamma-carboxylation of osteocalcin. Moderate increases of bone resorption and formation markers were observed after 6 months. These changes may contribute to fracture prevention in patients with osteoporosis.

Detailed Description

Not available

Study Timeline

• Study Start: 2002-02-01
• Status Verified: 2007-10
• Study First Submitted: 2007-10-23
• Study First Submitted QC: 2007-10-23
• Study First Posted: 2007-10-24
• Primary Completion: 2013-01
• Study Completion: 2013-01
• Last Update Submitted: 2018-10-26
• Last Update Posted: 2018-10-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 131

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Gamma-carboxylation

Secondary Outcome Measures

Name	Time	Method
Bone turnover marker