The effect of local fibrinogen administration on postoperative bleeding in CABG patients
- Conditions
- coronary artery bypass graft.Atherosclerotic heart disease
- Registration Number
- IRCT201510222804N9
- Lead Sponsor
- Vice chancellor for research, Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
age between 40-75 years old; elective CABG with CPB; constant surgeon; informed written consent.
The following conditions were considered as exclusion criteria: emergent or urgent surgery; age more than 75 years or less than 40 years old; diabetes mellitus (or any of its complications like diabetic ketoacidosis or non-ketonic hyperosmolar diabetic coma); any previous history of stroke or underlying cerebral vascular disease; history of deep vein thrombosis; history of underlying hematologic disorders; any carotid plaque creating significant stenosis (stenosis > 75%); underlying pulmonary disorders affecting the spirometry indices significantly (>50% decrease); acute renal failure; chronic kidney disease causing serum Cr>2mg/dL; hepatic failure causing liver function test failure (> 3 times than normal); off pump CABG; any unwanted complication in the operation period; re-starting CPB after weaning from bypass; pulmonary artery pressure >30 before operation; ejection fraction<30%; congestive heart failure.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Postoperative bleeding. Timepoint: Early 24 hours in postoperative period. Method of measurement: Postoperative amount of blood loss in chest tube bottles.
- Secondary Outcome Measures
Name Time Method Hematocrit level. Timepoint: Early 24 hours hematocrit in postoperative period. Method of measurement: Preoperative and postoperative hematocrit level.