The Influence of AMH on Ovarian Responsiveness to Ovulation Induction With GnRH in Women With PCOS
- Conditions
- Infertility
- Registration Number
- NCT02673632
- Lead Sponsor
- Ain Shams Maternity Hospital
- Brief Summary
The investigator suggests that PCOS women with high AMH levels are resistant to ovarian stimulation and may need adjustment of the dose of gonadotrophin.
- Detailed Description
There is a correlation between high levels of AMH and the severity of PCOS. Excessive AMH may have a negative effect on the sensitivity of the resting follicles to gonadotropins.
This is an observational prospective study to investigate the impact of circulating AMH on gonadotrophin induction in women with PCOS.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 30
Inclusion Criteria
- Women of age 18 - 35 years
- BMI 20 - 30 kg/m2
- Anovulatory infertility
- Diagnosis of PCOS based on Rotterdam consensus criteria (two of three criteria: Oligo/anovulation, hyperandrogenaemia and sonographic appearance of polycystic ovaries)
Exclusion Criteria
- Women Above 35 years or under 18 years
- Women with BMI above 30 kg/m2 or under 20 kg/m2
- Normally ovulating women
- Patients with marked hyperandrogenaemia were screened for congenital adrenal hyperplasia (by measuring serum concentration of 17alpha hydroxyl-progesterone) or Patients with Cushing syndrome (by measuring urinary free cortisol)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Good response to hMG therapy defined as occurrence of > 3 mature follicles after treatment. 30 days Good response to hMG therapy defined as occurrence of \> 3 mature follicles after treatment.
- Secondary Outcome Measures
Name Time Method