The Effects of Dual Task Training on Motor and Non-Motor Function in Individuals With Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 试验地点
- 2
- 主要终点
- Step Length During Gait
研究概览
简要总结
The primary aim of the proposed project is to characterize dual tasking (DT) deficits to improve motor, cognitive, and quality of life outcomes in individuals with Parkinson's disease (PD). Phase 1 of the intervention will involve an in-depth gait analysis on 15 individuals with PD. This gait analysis will utilize the Computer Assisted Rehabilitation Environment (CAREN) system, a virtual reality system with a fully integrated 3-D motion capture system. The purpose of Phase 1 is to generalize characteristics of gait and postural control during specific DT conditions. Phase 2 (N=20) involves the clinical translation of these findings. This phase will involve creating a clinical intervention based on the objective information gathered the CAREN system. The intervention will take place 3x/week for a total of 8 weeks. Interventional groups will include: 1) DT clinical group (N=10) and 2) Single task group (N=10). Outcome measures will be used at the beginning and end of the intervention to assess the feasibility and efficacy of the intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of idiopathic PD
- •Able to provide informed consent
- •Ability to ambulate ≥ 300ft with or without an assistive device
- •Hoehn and Yahr stage 2-4
排除标准
- •Undergone any surgical procedure for the treatment of PD, such as deep brain stimulation
- •Those who are considered to be high risk exercisers per American College of Sports Medicine exercise screening questionnaire
- •Musculoskeletal injury or neurological injury other than PD that would restrict physical activity
- •Inability to follow 2 step commands
- •Significant cognitive impairment as designated by ≥ 3 errors on the Short Portable Mental Status Questionnaire
研究组 & 干预措施
Dual Task Group
This group will complete an exercise intervention that involves performing dual tasking activities (simultaneously performing 2 things at once). This group will exercise 3x/wk for 8 weeks.
干预措施: Dual Task Group (Behavioral)
Single Task Group
This group will complete an exercise intervention that involves performing single task activities. The participant will perform motor tasks and cognitive tasks individually. This group will exercise 3x/wk for 8 weeks.
干预措施: Single Task Group (Behavioral)
结局指标
主要结局
Step Length During Gait
时间窗: Phase 1: baseline; Phase 2: baseline, end of treatment (8 weeks), and end of treatment +4 weeks
The average distance from heel strike of the less affected leg to heel strike of the more affected leg. Higher values indicate a longer step length.
Walking Speed During Gait
时间窗: Phase 1: baseline; Phase 2: baseline, end of treatment (8 weeks), and end of treatment +4 weeks
Average self-selected walking speed without dual tasking.
次要结局
- 2 Minute Walk Test(Phase 1: baseline; Phase 2: baseline, end of treatment (8 weeks), and end of treatment +4 weeks)
- Trail Making Test(Phase 2: baseline, end of treatment (8 weeks), and end of treatment +4 weeks)
- Quality of Life in Neurological Disorders Questionnaire(Phase 2: baseline, end of treatment (8 weeks), and end of treatment +4 weeks)
- Activities-specific Balance Confidence Scale(Phase 2: baseline, end of treatment (8 weeks), and end of treatment +4 weeks)
- Reaction Time(Phase 2: baseline, end of treatment (8 weeks), and end of treatment +4 weeks)