Exercise Target Brain Oscillations in Psychosis

Withdrawn

• Conditions: Psychosis; Schizophrenia; Schizoaffective Disorder
• Interventions: Other: Sprint Interval Training (SIT)

• Registration Number: NCT05338424
• Lead Sponsor: University of Minnesota

Brief Summary

Previous studies have shown that cardiorespiratory fitness (how well the heart and lungs are able to function during physical activity) is often reduced in people with psychosis. The goal of this research study is to test the hypothesis that aerobic exercise can lead to small changes in brain functioning that can influence visual perception and attention in psychosis. The type of aerobic exercise used in this study is called Sprint Interval Training, or "SIT". Information from this study will help to develop interventions that enhance cognition and maximize the quality of life for persons living with psychosis.

The exercise procedure used is called SIT, which involves training rigorously on a stationary bike for a short period of time followed by a resting period.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-04-04
• Study First Submitted QC: 2022-04-13
• Study First Posted: 2022-04-21
• Study Start: 2022-07-01
• Primary Completion: 2022-09-30
• Study Completion: 2022-09-30
• Status Verified: 2022-10
• Last Update Submitted: 2022-10-06
• Last Update Posted: 2022-10-10

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Meet diagnostic criteria for schizophrenia or schizoaffective disorder
• Are age 18-64
• Fluent in written and spoken English
• Have an outpatient status of at least 1 month prior to participation
• Has been on a stable dose of psychiatric medication for at least one month prior to participation (titration to a lower dose of psychotropic medications under supervision of a psychiatrist can be allowed at the discretion of the investigators)

Exclusion Criteria

• Current or possibility of current pregnancy (self-reported)
• Active suicidal ideation at screening or baseline assessments, or previous intent to act on suicidal ideation with a specific plan, preparatory acts, or an actual suicide attempt within the last 3 months, as indicated by the C-SSRS
• WTAR standardized score below 70
• American College of Sports Medicine contraindication to exercise

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Sprint Interval Training (SIT)	Sprint Interval Training (SIT)	The 1-session SIT protocol will include "Work" bouts performed at maximal intensity targets. Three "Work" bouts will be performed at 20-second intervals separated by 2 recovery bouts consisting of 2 minutes of low-intensity cycling. The SIT session will employ a standardized warm up and cool down of 3 minutes at a self-selected light intensity, per current guidelines. SIT sessions will take 15 minutes to complete.

Primary Outcome Measures

Name	Time	Method
Change in Individual Alpha Frequency	through study completion, on average 2 weeks	A prominent neural oscillatory rhythm measured from resting EEG.
Change in Visual Attention	through study completion, on average 2 weeks	Computerized tasks that measure speeded sustained attention.
Change in Visual Perception	through study completion, on average 2 weeks	Computerized tasks that measure speeded visual perception

Trial Locations

Locations (1)

University of Minnesota; 🇺🇸 Minneapolis, Minnesota, United States