ISRCTN80334919已完成未知
Double Blind Randomised Placebo Controlled Trial of Oral Co-trimoxazole in Pulmonary Fibrosis
The Peel Trust Fund (UK)0 个研究点目标入组 20 人开始时间: 2005年9月9日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 20
研究概览
简要总结
2008 results in https://www.ncbi.nlm.nih.gov/pubmed/17500020
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Male or female below 85 years old
- •2. Demonstrated breathlessness with oxygen desaturation below 90% on two baseline shuttle walking tests (SWT)
- •3. Physical examination, HRCT scan and pulmonary function test results compatible with IPF (with or without histological diagnosis)
- •4. New diagnosis of IPF without treatment or previous diagnosis on regular daily prednisolone
- •5. Symptoms of exertional dyspnoea affecting life quality
- •6. Normal glucose 6-phosphate dehydrogenase levels to avoid drug induced haemolysis. Normal vitamin B12 levels
排除标准
- •1. Recognised secondary causes of pulmonary fibrosis
- •2. Co-trimoxazole allergy or severe upper GI symptoms
- •3. Abnormal liver function tests or concurrent drug treatments that disturb liver function including azathioprine
- •4. Inability to perform the shuttle test due to musculoskeletal or cardiac causes
研究者
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