Electroencephalogram Coupled Non-invasive Brain Stimulation For Assessment of Cortical Excitability
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acquired Brain Injury
- Sponsor
- Mayo Clinic
- Primary Endpoint
- Change in Modified Rankin Scale
- Status
- Withdrawn
- Last Updated
- last year
Overview
Brief Summary
This research study is being done to look at the safety and diagnostic benefit of conducting an TMS(transcranial magnetic stimulation)-EEG measured before and after a brief experimental stimulation session using investigational devices repetitive TMS or transcranial direct current stimulation (tDCS).
Investigators
Zafer Keser
Principal Investigator
Mayo Clinic
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Change in Modified Rankin Scale
Time Frame: Baseline, 3 months
Measured using the Modified Rankin Scale (MRS) to assess functional outcome measure in stroke that utilizes a structured interview to assign subjects MRS grades 0-5 in a systematic way, grade 5 is severe disability, grade 0 is no symptoms at all
EEG and TMS-EEG functional connectivity
Time Frame: Baseline
EEG power in high and low frequency bands will be measured and power density maps will be created. TMS-evoked potentials and oscillations will be measured.
MRI based structural connectivity.
Time Frame: Baseline
Microstructural integrity of the networks will be quantified by using diffusion weighted imaging metrics such as mean diffusivity.
Change in Western Aphasia Battery (WAB) Aphasia (AQ) and Language Quotients (LQ)
Time Frame: Baseline, 3 months
Measured using Western Aphasia Battery Bedside Version. Higher score is better. Ranged from 0-100.
Change in neurological outcome (NIHSS)
Time Frame: Baseline, 3 months
Measured using the National Institutes of Health Stroke Scale (NIHSS). 15-item test to assess stroke-related neurologic deficits, each item scored with 3-5 grades with 0 as normal.