Clinical and genetic analysis of patients with primary failure of eruption (PFE) and their relatives
- Conditions
- K00.8Other disorders of tooth development
- Registration Number
- DRKS00028019
- Lead Sponsor
- CharitéCentrum für Zahn-, Mund- und Kieferheilkunde CC 3
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 30
The patient must be at least 12 years of age, as an asymmetric eruption of the first permanent molars becomes evident (to avoid premature (incorrect) diagnosis of the eruption disorder). Gender does not matter, but must be specified for the evaluation of the genetic analysis.
The number of study participants:
Spirit. 10 trios with PFE (affected children of two phenotypically healthy or affected parents or affected family members)
Absence of an impacted tooth in the pretherapeutic orthopantomogram (root growth of the teeth that have not yet erupted is not complete).
Abnormal tooth germ position, tooth germ malformation, bone deficit in patients with clefts, dilaceration.
Syndromic and systemic diseases
Teeth that do not erupt due to lack of space.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The aim of this study is to facilitate an easier clinical differential diagnosis of PFE, derive the causes of PFE in the genetic code through genetic analysis and localize the corresponding genes, to optimize or individualize the therapy of PFE based on the results of this study.<br><br>
- Secondary Outcome Measures
Name Time Method