HOWOLD-BP (HOW to Optimize eLDly systolic Blood Pressure) Trial

Chungbuk National University Hospital0 个研究点目标入组 3,177 人开始时间: 待定最近更新: 2019年4月23日

适应症

试验速览

暂无简介。

•1) aged above 65 years
•2) Hypertension patients
•- taking antihypertensive medications
•- newly diagnosed with hypertension (systolic pressure between 140 and 180 mmHg)
•3) possible self-care (Activities of Daily Living (ADL) score above 100)
•4) subjects with informed consent

•1) patients who did not agree to study
•2) past medical history of secondary hypertension or suspicious secondary hypertension
•3) resistant hypertension
•4) orthostatic hypotensioin at screening
•5) uncontrolled diabetes mellitus at screening (HbA1c above 10%)
•6) end stage renal disease (on hemodialysis or eGFR less than 15 mL/min/1.73m2)
•7) underwent acute coronary syndrome, cardiac surgery, or urgent percutaneous coronary intervention within recent 3 months
•8) systolic heart failure with ejection fraction less than 40%
•9) hypertrophic obstructive cardiomyopathy, aortic stenosis, moderate to severe valve disease, congenital heart disease
•10) diagnosed with acute cerebral infarction within recent 3 months
•11) diagnosed with moderate to severe retinopathy (retinal hemorrhage, visual impairment, microaneurysm) within recent 6 months
•12) wasting disease, autoimmune disease, connective tissue disease
•13) clinically significant liver disease or level of AST/ALT greater than 3 times upper normal range
•14) uncontrolled thyroid dysfunction
•15) enrolled other clinical trials within 4 months or plan to participant other clinical trials during our study
•16) other reasons limiting participant or progress of study according to investigators' judgement

发起方