Study of Rocuronium Onset Time According to Remifentanil Infusion

Not Applicable

Completed

• Conditions: Anesthesia
• Interventions: Drug: the order of drug administration

• Registration Number: NCT01030510
• Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary

The investigators therefore hypothesized that remifentanil could prolong the onset time of rocuronium, and evaluated the effect of remifentanil on the hemodynamic profiles (arterial pressure and heart rate) during the anesthetic induction sequence.

Detailed Description

It has been reported that co-administration of ephedrine reduced the onset time of neuromuscular block of rocuronium (1-3). It also provided an improved condition for the rapid tracheal intubation (2,4). This beneficial effect was attributed to the increased cardiac output and tissue perfusion to muscle, and therefore, a more rapid delivery of rocuronium to the neuromuscular junction was achieved (4-5). If so, any drugs which decrease cardiac output consequently can prolong the onset time of rocuronium.

Remifentanil is the first ultra-short acting opioid with a rapid onset. During the total intravenous anesthesia (TIVA) with propofol and remifentanil, prior administration of remifentanil could reduce the propofol infusion pain without other significant complications (6). However, remifentanil can decrease the arterial pressure and heart rate (7-8), so that it is likely to decrease the onset time of rocuronium for the opposite principle that ephedrine increases it.

The investigators therefore hypothesized that remifentanil could prolong the onset time of rocuronium, and evaluated the effect of remifentanil on the hemodynamic profiles (arterial pressure and heart rate) during the anesthetic induction sequence.

Study Timeline

• Study Start: 2009-12
• Study First Submitted: 2009-12-10
• Study First Submitted QC: 2009-12-10
• Study First Posted: 2009-12-11
• Primary Completion: 2010-10
• Study Completion: 2010-10
• Status Verified: 2011-12
• Last Update Submitted: 2011-12-14
• Last Update Posted: 2011-12-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 126

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
group R	the order of drug administration	In group R, remifentanil was infused first before administrating propofol and rocuronium
group P	the order of drug administration	in group P, remifentanil was administered last after the propofol and rocuronium injection

Primary Outcome Measures

Name	Time	Method
the onset time of rocuronium	3 minutes [after injection of rocuronium when general anesthesia is induced.]	Onset time of rocuronium was defined as the time from the end of its injection to the 95% depression of single twitch response, and it was measured by an anaesthesiologist, unaware of the group allocation.

Secondary Outcome Measures

Name	Time	Method
mean arterial pressure (MAP)	15 minutes [4 times; during the induction of general anesthesia as described below.]	1. before induction (baseline): When a patient enter the operating room,; 2. at rocuronium administration: immediately before injecting rocuronium,; 3. before tracheal intubation: immediately before intubation,; 4. after tracheal intubation: immediately after intubation.
heart rate (HR)	15 minutes [4 times; during the induction of general anesthesia as described below.]	1. before induction (baseline): When a patient enter the operating room,; 2. at rocuronium administration: immediately before injecting rocuronium,; 3. before tracheal intubation: immediately before intubation,; 4. after tracheal intubation: immediately after intubation.
cardiac output	15 minutes [4 times; during the induction of general anesthesia as described below.]	1. before induction (baseline): When a patient enter the operating room,; 2. at rocuronium administration: immediately before injecting rocuronium,; 3. before tracheal intubation: immediately before intubation,; 4. after tracheal intubation: immediately after intubation.
pain from the propofol infusion	1 minute [at the time when propofol is administered.]	When propofol is administered for the induction of anesthesia, we investigate the pain by propofol.
cough or chest wall rigidity from the remifentanil infusion	1 minute [at the time when remifentanil is infused.]	when remifentanil is infused, the cough or chest wall rigidity is checked.

Trial Locations

Locations (1)

Seoul National University Bundang Hospital; 🇰🇷 Seongnam-si, Gyeonggi-do, Korea, Republic of