Westlake Longevity Cohort

Recruiting

• Conditions: Aging; Neurodegenerative Diseases; Cardiometabolic Diseases

• Registration Number: NCT05256251
• Lead Sponsor: Westlake University

Brief Summary

The Westlake Longevity Cohort (We-Longevity) is a prospective cohort study among centenarians, nonagenarians and senior citizens living in Lishui, China. The primary aim of this cohort is to characterize the multi-omics molecular characteristics of healthy longevity and their dynamic trajectories. Another aim of We-Longevity is to investigate the association of dietary and lifestyle with the multi-omics molecular characteristics of healthy longevity, and to facilitate the development of personalized nutritional/lifestyle recommendation for the public.

Detailed Description

Aging is a major risk factor for most fatal diseases, such as Alzheimer's disease, type 2 diabetes, cardiovascular disease and cancer. Global population aging is becoming increasingly serious, and this trend is mainly driving the annual increase in the prevalence of aging-related diseases. Healthy longevity are influenced by a variety of factors, such as diet structure, lifestyle, ecological environment, gut microbiome and genetics. At present, the researches on healthy longevity are mainly focused on Drosophila, nematodes and mouse models, and few studies on longevity population. Centenarians and nonagenarians are the best objects to study healthy longevity. However, the multi-omics molecular characteristics and regulatory mechanism of healthy longevity in human are still unclear. There, the present We-Longevity design includes centenarians, nonagenarians, and senior citizens. We will determine the fecal/serum metabolome, gut microbiome serum proteome and genome, together with diet, lifestyle and disease information.

Study Timeline

• Study Start: 2021-11-15
• Study First Submitted: 2021-11-15
• Study First Submitted QC: 2022-02-21
• Study First Posted: 2022-02-25
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-30
• Last Update Posted: 2025-04-03
• Primary Completion: 2025-11-14
• Study Completion: 2031-11-14

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1200

Inclusion Criteria

• Participants aged 50 years or order.
• Participants live in Lishui, China.
• Participants intend to remain in Lishui for ≥3 years.

Exclusion Criteria

• Participants with cancer, serious medical disorders or infectious diseases.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
aging	36 months	Physical frailty will be evaluated by using Fried's criteria.
Gut microbiota	36 months	Fecal microbiome will be analyzed by 16S rRNA gene sequencing and metagenome sequencing.

Secondary Outcome Measures

Name	Time	Method
Cognitive function	36 months	Cognitive function will be evaluated by using Mini-Mental State Examination (MMSE).
Blood glucose examination of blood samples	36 months	Blood glucose will be analyzed by automatic biochemical analyser.
Blood blood lipids examination of blood samples	36 months	Blood blood lipids (HDL, LDL, TC and TG) will be analyzed by automatic biochemical analyser.

Trial Locations

Locations (1)

Lishui City People's Hospital; 🇨🇳 Lishui, Zhejiang, China