Longevity in Russia

Recruiting

• Conditions: Aging Disorder; Frailty; Age-related Cognitive Decline; LONGEVITY 1; Aging

• Registration Number: NCT06268132
• Lead Sponsor: Center for Strategic Planning, of the Federal Medical and Biological Agency

Brief Summary

This is an observational cohort study of long-living adults (participants aged 90 and above) from the Central Federal District of Russia.

The study seeks to determine the genetic and cellular and molecular determinants of healthy longevity and to assess the impact of lifestyle and socioeconomic and environmental factors on healthy longevity.

The study is expected to result in the development of a panel of markers of healthy longevity and/or a model of healthy aging based on the analysis of all factors under consideration.

Detailed Description

The study involves a long-term observation of a cohort of long-living adults. During the first visit, a medical professional will take a detailed medical history and perform a comprehensive geriatric assessment (for 15 geriatric syndromes), and physical examination. The participants will have their biomaterials sampled for basic and extended blood biochemistry testing, telomere length measurement, common urine tests and subsequent biobanking and additional studies: whole genome sequencing, DNA methylation analysis, transcriptome analysis, and 16S RNA sequencing of stool and saliva.

Follow-up checks will be carried out once a year by phone or during additional visits.

The study seeks to identify the genetic, epigenetic, and metagenomic determinants associated with the successful and unsuccessful aging phenotypes, mortality, and survival in long-living individuals.

Study Timeline

• Study Start: 2019-12-25
• Status Verified: 2024-02
• Study First Submitted: 2024-02-13
• Study First Submitted QC: 2024-02-13
• Study First Posted: 2024-02-20
• Last Update Submitted: 2024-02-20
• Last Update Posted: 2024-02-22
• Primary Completion: 2024-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 4000

Inclusion Criteria

• Informed consent
• 90 years of age or above

Exclusion Criteria

• Refusal to participate or to provide informed consent;
• Any other criteria deemed reasons for exclusion by the Principal Investigator.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mortality among long-living adults	at least 1 year after inclusion in the study	Mortality among long-living adults within at least 1 year after inclusion in the study and factors associated with mortality will be assessed.
Morbidity among long-living adults	at least 1 year after inclusion in the study	Morbidity among long-living adults within at least 1 year after inclusion in the study and factors associated with morbidity will be assessed.

Secondary Outcome Measures

Name	Time	Method
Social, economic, and medical- history-related determinants	at least 2 years after inclusion in the study	Identification of social, economic, and medical- history-related determinants of successful and unsuccessful aging, geriatric syndromes
Metagenomic determinants	at least 2 years after inclusion in the study	Identification of the metagenomic determinants (16S-rSeq) of successful and unsuccessful aging, geriatric syndromes
Aging phenotypes	at least 2 years after inclusion in the study	Identification of successful and unsuccessful aging phenotypes
Epigenetic determinants	at least 2 years after inclusion in the study	Identification of the epigenetic determinants (methylation sites) of successful and unsuccessful aging, geriatric syndromes
Genetic determinants	at least 2 years after inclusion in the study	Identification of the genetic determinants of successful and unsuccessful aging, geriatric syndromes

Trial Locations

Locations (1)

RUSSIAN CLINICAL AND RESEARCH CENTER OF GERONTOLOGY, Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation; 🇷🇺 Moscow, Russian Federation