To compare carotid blood vessel ultrasound examination and FloTrac instrument for assessing the function of heart during liver transplantation surgery.

Not yet recruiting

• Conditions: End stage liver disease patients undergoing liver transplantation surgery

• Registration Number: CTRI/2018/02/012080
• Lead Sponsor: Dept of Anaesthesia I L B S

Brief Summary

The primary purpose of this trial to authenticate cardiac output and fluid responsiveness measurements obtained with carotid Doppler assessment by correlating with an already existing hemodynamic monitoring technique like FloTrac during liver transplantation surgery. There are many challenges posed by this complex surgery and liver disease itself in accurate hemodynamic assessment. Existing methods donot accurately assess hemodynamic status due to these limitations eg. high vasopressors after reperfusion. Our hypothesis is that carotid artery is a site which is minimally affected by liver disease and the difficulties of liver transplant surgery. So this site can be used for hemodynamic assessment with a non-invasive modality like ultrasound during liver transplant.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-03
• Last Update Posted: 2018-02-22

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

all end stage liver disease patients undergoing liver transplantation surgery.

Exclusion Criteria

Age less than 18 years pregnancy Rhythm disturbances pre-operative and intra-operative dialysis.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation of cardiac output and stroke volume variation obtained with FloTrac and Carotid artery Doppler derived Cardiac output and Flowtime	Immediately after induction of anaesthesia, 1 hour into dissection phase, 3 hours into dissection phase, anhepatic phase, post-reperfusion phase

Secondary Outcome Measures

Name	Time	Method
Effect of vasopressors, hemoglobin on discrepancy of cardiac output measurements between two methods	Immediately after induction of anaesthesia, 1 hour into dissection phase, 3 hours into dissection phase, anhepatic phase, post-reperfusion phase

Trial Locations

Locations (1)

Institute of liver and Biliary Sciences; 🇮🇳 South, DELHI, India

Institute of liver and Biliary Sciences

🇮🇳South, DELHI, India

Nandakumar K

Principal investigator

7835056142

drnandakumarmd@yahoo.com