The Effect of Ischemic Pre-Conditioning on the Rate of Recovery Following Exercise-Induced Muscle Damage: a Randomized Control Trial
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 24
- Locations
- 2
- Primary Endpoint
- Change from baseline in maximal voluntary contraction
Study Overview
Brief Summary
Strenuous exercise or exercise involving eccentric muscle contractions can lead to muscle damage and changes in muscle function; this is known as exercise-induced muscle damage (EIMD). It is known that brief, repeated periods of ischemia followed by reperfusion, known as Ischemic Preconditioning (IPC) cause a delay in cell injury in cardiac muscle as well as in various other organs.
Therefore the purpose of this study is to:
- Quantify the use of IPC in recovery following EIMD.
- Identify any effect of IPC during recovery on muscle function
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Physically Active Males
Exclusion Criteria
- •Muscular skeletal disorders
Outcomes
Primary Outcomes
Change from baseline in maximal voluntary contraction
Time Frame: pre exercise, 24 hours post, 48 hours post and 72 hours post exercise
Isometric MVC of the participants' dominant knee extensors was assessed using a strain gauge. MVCs were performed for 3 s with a 60 s rest between each repetition. The change in MVC will be determined 24, 48 and 72 hours following pre exercise conditions.
Secondary Outcomes
- Change from baseline in Creatine kinase(pre exercise, 24 hours post, 48 hours post and 72 hours post exercise)
- Change from baseline in Limb girth(pre exercise, 24 hours post, 48 hours post and 72 hours post exercise)
- Change from baseline in Muscle soreness(pre exercise, 24 hours post, 48 hours post and 72 hours post exercise)
- Chnage from baseline in Vertical jump(pre exercise, 24 hours post, 48 hours post and 72 hours post exercise)
Investigators
Stephen Patterson
Senior Lecturer Exercise Physiology
St Mary's University College