Pilot Study of Remote Ischemic Preconditioning in Heart Failure

Not Applicable

Completed

• Conditions: Heart Failure; Left Ventricular Dysfunction
• Interventions: Other: Remote ischemic preconditioning; Other: Sham Control

• Registration Number: NCT01128790
• Lead Sponsor: University Health Network, Toronto

Brief Summary

The purpose of this study is to determine the effect of remote ischemic preconditioning on exercise capacity in patients with heart failure.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-10
• Study First Submitted: 2009-12-17
• Study First Submitted QC: 2010-05-21
• Study First Posted: 2010-05-24
• Primary Completion: 2011-06
• Study Completion: 2011-06
• Status Verified: 2013-12
• Last Update Submitted: 2013-12-20
• Last Update Posted: 2013-12-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

• LV ejection fraction <40%
• NYHA functional class II-IV
• Non ischemic cardiomyopathy
• Stable

Read More

Exclusion Criteria

• recent cardiovascular hospitalization (within last 4 weeks)
• ischemic cardiomyopathy
• diabetes mellitus
• peripheral neuropathy
• ventricular assist device
• contraindications to exercise stress testing

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
remote ischemic preconditioning	Remote ischemic preconditioning	4 cycles of 5 mins upper limb ischemia induced by blood pressure cuff inflation 20mmHg above systolic blood pressure
Sham control	Sham Control	4 x 5 mins of upper limb blood pressure cuff inflation to 10mmHg (non-occlusive)

Primary Outcome Measures

Name	Time	Method
Exercise performance - VO2, exercise time, exercise workload, anaerobic threshold	1 week

Trial Locations

Locations (1)

Toronto General Hospital; 🇨🇦 Toronto, Ontario, Canada