NCT02805036已完成不适用
Comparison of the Hemodynamic Safety of Two Common Alveolar Recruitment Manoeuvres With Regard to Cardiac Output in a Surgical Intensive Care Unit: a Randomized Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Variations in cardiac output induced by each type of AR manoeuvre
研究概览
简要总结
Protective ventilation - combining a low tidal volume (between 6 and 8 ml/kg) and alveolar recruitment (AR) manoeuvres repeated every 30 minutes - is currently the standard of care for decreasing morbidity associated with mechanical ventilation.
In contrast, there is no consensus on the type of recruitment manoeuvre, which varies from one centre to another and from one study to another.
The investigators intend to compare two currently used AR techniques with regard to their ventilatory efficacy and hemodynamic safety:
- An end-tidal plateau at 30 cmH20 for 30 seconds.
- An end-tidal plateau at 10 cmH20 above the patient's plateau pressure for 30 seconds, without exceeding 30 cmH20.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All sedated, intubated, mechanically ventilated adult patients (over-18) admitted to the surgical intensive care unit and equipped with a central venous catheter and an arterial catheter.
- •Good echogenicity
- •Social security coverage
排除标准
- •Pregnancy
- •Cardiac arrhythmia
- •Poor echogenicity
- •Legal guardianship or incarceration
- •Systolic blood pressure ≤90 mmHg
- •Respiratory distress
- •Patients admitted on an emergency basis (first 24 hours), i.e. not for elective surgery
结局指标
主要结局
Variations in cardiac output induced by each type of AR manoeuvre
时间窗: Day 0
次要结局
- Variations in PaO2 variations induced by each type of AR manoeuvre(Day 0)
研究者
研究点 (1)
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