Comparison Between Limited Driving Pressure Ventilation and Conventional Mechanical Ventilation Strategies in Medical Intensive Care Patients With Acute Respiratory Failure
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- on Invasive Mechanical Ventilation
- Sponsor
- Mahidol University
- Enrollment
- 126
- Locations
- 1
- Primary Endpoint
- Lung injury score
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Background An appropriated mechanical ventilator setting for acute respiratory failure results of ventilator associated lung injury. Limited driving pressure and low tidal volume ventilation strategies show benefits decreasing mortality in acute respiratory distress syndrome, but there are no data in simple acute respiratory failure.
Detailed Description
Background An appropriated mechanical ventilator setting for acute respiratory failure results of ventilator associated lung injury. Limited driving pressure and low tidal volume ventilation strategies show benefits decreasing mortality in acute respiratory distress syndrome, but there are no data in simple acute respiratory failure. To compare lung injury score (LIS, Murray score) after invasive mechanical ventilation 7 days between groups of limited driving pressure ventilation versus low tidal volume ventilation strategies.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age ≥ 18 year old MICU patient
- •On Invasive mechanical ventilator less than 24 hr. before randomization
Exclusion Criteria
- •Suspected death within 48 hr. after randomization
- •patients with tracheostomy tube
- •Pregnancy
- •Do not attempt resuscitation order
- •Patient with ECMO before randomization
Outcomes
Primary Outcomes
Lung injury score
Time Frame: Day 7 after invasive mechanical ventilation
Lung injury score (LIS, Murray score)
Secondary Outcomes
- New onset of ARDS(Upto 28 days)
- 28 days Mortality(Upto 28 days)