Comparison Between Limited Driving Pressure Ventilation and Conventional Mechanical Ventilation Strategies in Medical Intensive Care Patients With Acute Respiratory Failure

Not Applicable

Completed

• Conditions: ARDS; Respiratory Failure; on Invasive Mechanical Ventilation

• Registration Number: NCT04035915
• Lead Sponsor: Mahidol University

Brief Summary

Background An appropriated mechanical ventilator setting for acute respiratory failure results of ventilator associated lung injury. Limited driving pressure and low tidal volume ventilation strategies show benefits decreasing mortality in acute respiratory distress syndrome, but there are no data in simple acute respiratory failure.

Detailed Description

Background An appropriated mechanical ventilator setting for acute respiratory failure results of ventilator associated lung injury. Limited driving pressure and low tidal volume ventilation strategies show benefits decreasing mortality in acute respiratory distress syndrome, but there are no data in simple acute respiratory failure.

To compare lung injury score (LIS, Murray score) after invasive mechanical ventilation 7 days between groups of limited driving pressure ventilation versus low tidal volume ventilation strategies.

Study Timeline

• Study Start: 2019-07-25
• Study First Submitted: 2019-07-25
• Study First Submitted QC: 2019-07-25
• Study First Posted: 2019-07-29
• Primary Completion: 2020-12-31
• Study Completion: 2021-03-31
• Status Verified: 2021-09
• Last Update Submitted: 2021-09-23
• Last Update Posted: 2021-09-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 126

Inclusion Criteria

• Age ≥ 18 year old MICU patient
• On Invasive mechanical ventilator less than 24 hr. before randomization

Exclusion Criteria

• Suspected death within 48 hr. after randomization
• patients with tracheostomy tube
• Pregnancy
• Do not attempt resuscitation order
• Patient with ECMO before randomization

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Lung injury score	Day 7 after invasive mechanical ventilation	Lung injury score (LIS, Murray score)

Secondary Outcome Measures

Name	Time	Method
New onset of ARDS	Upto 28 days	New onset of ARDS
28 days Mortality	Upto 28 days	28 days Mortality

Trial Locations

Locations (1)

Mahidol university; 🇹🇭 Bangkok Noi, Bangkok, Thailand