Comparison Between Volume Controlled Ventilation and Pressure Controlled Ventilation

Assistance Publique - Hôpitaux de Paris1 site in 1 country36 target enrollmentJanuary 2005

ConditionsObesity Reduced Lung Compliance.Anesthesia.Laparoscopy.

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Obesity
Sponsor: Assistance Publique - Hôpitaux de Paris
Enrollment: 36
Locations: 1
Primary Endpoint: Plateau pressures generated by mechanical ventilation after 45 minutes of pneumoperitoneum.
Status: Completed
Last Updated: 20 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

To assess the potential benefits on mechanical ventilation plateau pressure of pressure controlled mode versus volume controlled mode for laparoscopic bariatric surgery in obese patients (BMI > 35). High plateau pressures encountered in obese patients due to their reduced pulmonary compliance could be lowered using pressure controlled mechanical ventilation.

Detailed Description

All patients are over 18 years old and give their inform consent after approval of the study protocol by an ethic committee. Anesthesia is standardized and all patients are intubated. Precise protocols are used to perform pressure and volume controlled ventilation in order to regulate End-Tidal CO2 between 33 and 35 mmHg. Primary goal is comparison of plateau pressures observed in the 2 ventilation modes after 45 minutes of pneumoperitoneum. Secondary goals are : comparison of PaO2 and PaCO2 after 45 minutes of pneumoperitoneum and after 2 hours spent in post-anesthesia care unit ; comparison of total respiratory resistances and peak flow generated between the 2 modes.

Registry

clinicaltrials.gov

Start Date

January 2005

End Date

June 2005

Last Updated

20 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Assistance Publique - Hôpitaux de Paris

Eligibility Criteria

Inclusion Criteria

•patients are over 18 years old and give their inform consent
•morbid obesity(BMI\>35)
•laparoscopic bariatric surgery

Exclusion Criteria

Not provided

Outcomes

Primary Outcomes

Plateau pressures generated by mechanical ventilation after 45 minutes of pneumoperitoneum.

Secondary Outcomes

Comparison of PaO2 and PaCO2 after 45 minutes of pneumoperitoneum and after 2 hours spent in post-anesthesia care unit ; comparison of total respiratory resistances and peak flow generated between the 2 modes.