Comparison Between Volume Controlled Ventilation and Pressure Controlled Ventilation

Not Applicable

Completed

• Conditions: Obesity; Reduced Lung Compliance.; Anesthesia.; Laparoscopy.

• Registration Number: NCT00224653
• Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Brief Summary

To assess the potential benefits on mechanical ventilation plateau pressure of pressure controlled mode versus volume controlled mode for laparoscopic bariatric surgery in obese patients (BMI \> 35). High plateau pressures encountered in obese patients due to their reduced pulmonary compliance could be lowered using pressure controlled mechanical ventilation.

Detailed Description

All patients are over 18 years old and give their inform consent after approval of the study protocol by an ethic committee. Anesthesia is standardized and all patients are intubated. Precise protocols are used to perform pressure and volume controlled ventilation in order to regulate End-Tidal CO2 between 33 and 35 mmHg. Primary goal is comparison of plateau pressures observed in the 2 ventilation modes after 45 minutes of pneumoperitoneum. Secondary goals are : comparison of PaO2 and PaCO2 after 45 minutes of pneumoperitoneum and after 2 hours spent in post-anesthesia care unit ; comparison of total respiratory resistances and peak flow generated between the 2 modes.

Study Timeline

• Study Start: 2005-01
• Study Completion: 2005-06
• Status Verified: 2005-09
• Study First Submitted: 2005-09-16
• Study First Submitted QC: 2005-09-16
• Study First Posted: 2005-09-23
• Last Update Submitted: 2006-04-12
• Last Update Posted: 2006-04-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• patients are over 18 years old and give their inform consent
• morbid obesity(BMI>35)
• laparoscopic bariatric surgery

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Exclusion Criteria

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Plateau pressures generated by mechanical ventilation after 45 minutes of pneumoperitoneum.

Secondary Outcome Measures

Name	Time	Method
Comparison of PaO2 and PaCO2 after 45 minutes of pneumoperitoneum and after 2 hours spent in post-anesthesia care unit ; comparison of total respiratory resistances and peak flow generated between the 2 modes.

Trial Locations

Locations (1)

Georges Pompidou European Hospital; 🇫🇷 Paris, Ile de France, France