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Clinical Trials/NCT01573481
NCT01573481
Completed
Not Applicable

Pressure Controlled Ventilation Versus Pressure Support Ventilation During the Night: New Strategy of Mechanical Ventilation Weaning?

Centre Hospitalier Universitaire, Amiens1 site in 1 country19 target enrollmentJanuary 1, 2012
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ConditionsWeaning FailureCOPD Exacerbation

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Weaning Failure
Sponsor
Centre Hospitalier Universitaire, Amiens
Enrollment
19
Locations
1
Primary Endpoint
Weaning duration
Status
Completed
Last Updated
7 months ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

The purpose of the study is to compare pressure controlled continuous mandatory ventilation versus pressure support ventilation during the night for weaning to mechanical ventilation in chronic obstructive pulmonary disease patients and their impact onto sleep quality.

Registry
clinicaltrials.gov
Start Date
January 1, 2012
End Date
January 1, 2015
Last Updated
7 months ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • •The patient and/or legal representative of the patient has provided a written informed consent before inclusion in the study
  • •The patients is hospitalized in respiratory and critical care unit (university hospital of AMIENS, FRANCE)
  • •the patient is mechanically ventilated (ventilator model : puritan-bennett B840)
  • •Pulmonary disease,chronic obstructive (Spirometry and Blood Gas Analysis in chronic state before admission)
  • •stable cardiovascular status (cardiac frequency \< 140 beats/min and systolic blood pressure : 90-160 mmHg without catecholamines)
  • •midazolam \< 0,05mg/kg/h
  • •sufentanyl \< 0,05µ/kg/h
  • •the disorder that caused respiratory failure and prompted mechanical ventilation is treated
  • •the clinician suspects the patient may be ready to begin the weaning process
  • •inspiratory oxygen fraction (FiO2) \< 50%

Exclusion Criteria

  • •sleep apnea, central
  • •narcolepsy
  • •Encephalopathy, Metabolic AND Encephalitis

Outcomes

Primary Outcomes

Weaning duration

Time Frame: between one to 21 days (the study will begin when patient presents weaning criteria and will stop 48 days after extubation.)

weaning duration in days (from the first day with spontaneous ventilation to extubation)

Secondary Outcomes

  • weaning failure(48 hours)
  • Quantity and quality of sleep(1 to 21 days)

Study Sites (1)

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