The role of microparticles bearing active tissue factor in cancer and thrombosis: The Bouillaud Study
- Conditions
- cancermalignancy10027656
- Registration Number
- NL-OMON32659
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 700
Inclusion Criteria
patients diagnosed with carcinomas(epithelial tumors) of the gastrointestinal tract including colorectal, pancreatic,stomach and bowel. Patients with cancer of the genito-urinary tract (i.e prostate and renal tumours). Also patients with adeno-and squamous carcinomas of the lung, cancer of the ovaries and hematological malignancies.
Exclusion Criteria
pregnant women
recent immobilization
systemic (chemo)therapy for metastatic disease
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Study variables; MP-TF activity, MP phenotypes, cytokines, FV Leiden, FII<br /><br>mutations, sTF and sP-selectin.<br /><br><br /><br>We will compare the results of the study variables (see above) between the<br /><br>different cancer types and between patients and healthy volunteers.<br /><br>The level of MP-TF activity and MP phenotypes will also be compared with<br /><br>patients who did and did not developed thrombosis, patients who did and did not<br /><br>undergo a change in the stage of their disease and survival between the<br /><br>different groups of patients.</p><br>
- Secondary Outcome Measures
Name Time Method <p>MP-TF activity, MP-phenotypes, FV Leiden and FII mutations in the controle<br /><br>group.</p><br>