Post-operative Pain Reduction

Not Applicable

• Conditions: Effects of the Elements
• Interventions: Drug: Conventional calcium hydroxide paste; Drug: Combined Calcium hydroxide with silver nanoparticle; Drug: Calcium hydroxide nanoparticle

• Registration Number: NCT04338633
• Lead Sponsor: Minia University

Brief Summary

Recruited patients with necrotic pulp after application of conventional calcium hydroxide paste are assigned to group, Calcium hydroxide nanoparticle group and Combined Calcium hydroxide with silver nanoparticle group and record postoperative pain afterwards.

Detailed Description

The investigator will recruit patients who are found eligible to the criteria, conventional calcium hydroxide paste , Calcium hydroxide nanoparticle and Combined Calcium hydroxide with silver nanoparticle . After 48 hours, patients will be randomly assigned to removal of intracanal medication

After the visit, patients will be asked to record post operative pain by Numerical Rating Scale)in a given sheet

Study Timeline

• Status Verified: 2020-04
• Study Start: 2020-04
• Study First Submitted: 2020-04-06
• Study First Submitted QC: 2020-04-06
• Last Update Submitted: 2020-04-06
• Study First Posted: 2020-04-08
• Last Update Posted: 2020-04-08
• Primary Completion: 2020-11
• Study Completion: 2020-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• • Medically free patients.

  • Patient's age between 25-50 years.
  • Sex includes both male and female.
  • Radiographic evidence of a periapical radiolucent lesion associated with tooth.
  • Necrotic pulp as indicated by thermal pulp testing.
  • No history of previous endodontic treatment of the tooth.

Exclusion Criteria

• • Teeth with unfavorable conditions for rubber-dam application.

  • Teeth with acute periapical abscesses swelling.
  • Medically compromised patients.
  • Immature teeth with open apices.
  • Multi rooted teeth.
  • Pregnant women.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Conventional calcium hydroxide paste	Conventional calcium hydroxide paste	Application of Conventional calcium hydroxide paste
Combined Calcium hydroxide with silver nanoparticle	Combined Calcium hydroxide with silver nanoparticle	Application of Combined Calcium hydroxide with silver nanoparticle
Calcium hydroxide nanoparticle	Calcium hydroxide nanoparticle	Application of Calcium hydroxide nanoparticle

Primary Outcome Measures

Name	Time	Method
change in post operative pain (Visual Analogue Scale)	Intrappointment at 4,24,48,72 and 96 hours ]	Numerical (0-10)

Trial Locations

Locations (1)

Faculty of Dentistry, Minia University; 🇪🇬 Minya, Egypt