Infusion Laboratory: Protocol 4 (Dihydrexidine) - 13
Phase 1
- Conditions
- Cocaine-Related Disorders
- Registration Number
- NCT00000348
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Brief Summary
The purpose of this study is to evaluate safety issues pertaining to dihydrexidine (DHX), to cocaine, and to its interaction, and to determine how pretreatment with DHX modifies the subjective as well as physiological effects of cocaine infusion.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
M/F, ages 21-50. Meet DSM-IV criteria for cocaine dependence. Agree to conditions of the study and sign informed consent.
Exclusion Criteria
Psychiatric disorder that requires medication therapy. History of seizures. Pregnant and/or nuring women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics. Acute hepatitis. Other medical condtions that deem participation to be unsafe.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Degree of drug craving Characterization of study population Frequency of IV drug use and sexual risk behaviors Type and severity of stimulant withdrawal symptoms Clinical physiological response to cocaine challen History, incidence and amount of drug use Population incidence of symptoms of depression, po Evidence of change in neurophysiology and brain ac Evidence of change in subjective responses to coca Degree to which study medication influences change
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Friends Research Institute
🇺🇸Los Angeles, California, United States