Transcranial Magnetic Stimulation-based Assessment of Mental Training Effects on Motor Learning in Healthy Participants
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 556
- 试验地点
- 1
- 主要终点
- Evolution of movement accuracy - Sequence 1
研究概览
简要总结
The general purpose of this research project is to analyze the specific role of motor imagery on motor learning, assessed through corticospinal excitability measurements and behavioral data collection. This project is based on four sequences. For Sequence 1, the main objective is to examine the effect of mental training on movement speed and accuracy in a manual motor sequence task, as well as the influence of sensory feedback in immediate post-test (i.e., execution of a similar, but not identical, manual motor sequence, other manual tasks) on performance in delayed post-test. The secondary objective will be to examine corticospinal changes (i.e., amplitude of motor evoked potentials) induced by mental training, by measuring the amplitude of motor evoked potentials before and after mental training. For Sequence 2, the main objective is to examine the impact of a motor disturbance induced by a robotic arm at different intervals during the motor imagery process. The secondary objective will be to examine the corticospinal changes (i.e. amplitude of evoked motor potentials) induced by mental training as a function of the applied perturbations, before and after perturbation. For Sequence 3, the main objective will be to examine the influence of neuroplasticity on the quality of mental training. More specifically, the investigators will study the links between brain plasticity and motor learning through mental training. The secondary objective will be to examine the corticospinal changes (i.e. amplitude of evoked motor potentials) induced by mental training at different levels of the neuromuscular system (cortical, cervicomedullar, peripheral) after a training period. For Sequence 4, the main objective will be to examine the effect of short-term arm-immobilization of on the retention of motor learning induced by mental training. The secondary objective will be to examine the corticospinal changes (i.e., amplitude of motor evoked potentials) induced by of short-term arm-immobilization, or by transcranial direct current stimulation (tDCS), on motor learning. The results of this fundamental research project will allow a better understanding of neurophysiological and behavioral mechanisms that underlie motor learning through motor imagery. The results will allow to efficiently consider inter-individual specificities and will thus open up to clinical research perspectives, towards the establishment of adapted motor rehabilitation protocols.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female between 18 and 60 years old
- •Having given written informed consent
- •Affiliated to a social security scheme
排除标准
- •History of psychiatric illness (declarative)
- •Person under guardianship, curatorship, safeguard of justice
- •Neurological problem that could bias the results of the study (declarative)
- •Personal or family history of epilepsy
- •Person deprived of liberty by judicial or administrative decision
- •Person hospitalized without consent and not subject to legal protection, and person admitted to a health or social institution for purposes other than that of the research
- •Person subject to an exclusion period for another research
- •Pregnant women or women of childbearing age not using known contraception
- •Breastfeeding women
- •Person on medication that could influence neurophysiological measures (neuroleptics, anxiolytics, antidepressants)
- •Person carrying :
- •pacemaker or other device that could interfere with the magnetic field
- •Implants (mechanical or electronic: cochlear implants, neural or cardiac pacemakers, infusion pumps, magnetic aneurysm clips, etc.)
- •Metallic foreign bodies in the eye or nervous system
- •Metallic objects (tattoos, piercings, etc.)
研究组 & 干预措施
Sequence 2 - Mental training with perturbation during preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
干预措施: Mental training (Other)
Sequence 4 - Anodal - Long follow-up
Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training
干预措施: Mental training (Other)
Sequence 4 - Control
Transcranial magnetic stimulation Motor task Mental training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 4 - Control
Transcranial magnetic stimulation Motor task Mental training
干预措施: Mental training (Other)
Sequence 2 - Physical training with perturbation during preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 1 - Training with same task - Long follow-up
Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation Mental training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 1 - Training with same task - Long follow-up
Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation Mental training
干预措施: Mental training (Other)
Sequence 1 - Training with same task - Short follow-up
Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation Mental training
干预措施: Mental training (Other)
Sequence 1 - Training with same task - Short follow-up
Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation Mental training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 1 - Control
Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation No mental training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 1 - Training with different tasks - Long follow-up
Motor task (different task in immediate post test) Transcranial magnetic stimulation Mental training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 1 - Training with different tasks - Long follow-up
Motor task (different task in immediate post test) Transcranial magnetic stimulation Mental training
干预措施: Mental training (Other)
Sequence 1 - Training with different tasks - Short follow-up
Motor task (different task in immediate post test) Transcranial magnetic stimulation Mental training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 1 - Training with different tasks - Short follow-up
Motor task (different task in immediate post test) Transcranial magnetic stimulation Mental training
干预措施: Mental training (Other)
Sequence 1 - Training with muscle contractions - Long follow-up
Motor task (isometric muscle contractions in immediate post test) Transcranial magnetic stimulation Mental training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 1 - Training with muscle contractions - Long follow-up
Motor task (isometric muscle contractions in immediate post test) Transcranial magnetic stimulation Mental training
干预措施: Mental training (Other)
Sequence 1 - Training with muscle contractions - Short follow-up
Motor task (isometric muscle contractions in immediate post test) Transcranial magnetic stimulation Mental training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 1 - Training with muscle contractions - Short follow-up
Motor task (isometric muscle contractions in immediate post test) Transcranial magnetic stimulation Mental training
干预措施: Mental training (Other)
Sequence 2 - Physical training with perturbation during preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
干预措施: Robotic arm (Device)
Sequence 2 - Physical training with perturbation during preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
干预措施: Physical training (Other)
Sequence 2 - Physical training with perturbation during preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 2 - Physical training with perturbation during preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
干预措施: Robotic arm (Device)
Sequence 2 - Physical training with perturbation during preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
干预措施: Physical training (Other)
Sequence 2 - Physical training with perturbation after preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 2 - Physical training with perturbation after preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
干预措施: Robotic arm (Device)
Sequence 2 - Physical training with perturbation after preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
干预措施: Physical training (Other)
Sequence 2 - Physical training with perturbation after preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 2 - Physical training with perturbation after preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
干预措施: Robotic arm (Device)
Sequence 2 - Physical training with perturbation after preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
干预措施: Physical training (Other)
Sequence 2 - Mental training with perturbation during preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 2 - Mental training with perturbation during preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
干预措施: Robotic arm (Device)
Sequence 2 - Mental training with perturbation during preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
干预措施: Mental training (Other)
Sequence 2 - Mental training with perturbation during preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 2 - Mental training with perturbation during preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
干预措施: Robotic arm (Device)
Sequence 2 - Mental training with perturbation after preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 2 - Mental training with perturbation after preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
干预措施: Robotic arm (Device)
Sequence 2 - Mental training with perturbation after preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
干预措施: Mental training (Other)
Sequence 2 - Mental training with perturbation after preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 2 - Mental training with perturbation after preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
干预措施: Robotic arm (Device)
Sequence 2 - Mental training with perturbation after preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
干预措施: Mental training (Other)
Sequence 3 - Training (same task) - Long follow-up
Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Transcranial magnetic stimulation (Device)
Sequence 3 - Training (same task) - Long follow-up
Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Peripheral Nerve Stimulation (Device)
Sequence 3 - Training (same task) - Long follow-up
Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Paired Associative Stimulation (Device)
Sequence 3 - Training (same task) - Long follow-up
Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Cervicomedullar stimulation (Device)
Sequence 3 - Training (same task) - Long follow-up
Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Mental training (Other)
Sequence 3 - Training (same task) - Short follow-up
Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Transcranial magnetic stimulation (Device)
Sequence 3 - Training (same task) - Short follow-up
Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Peripheral Nerve Stimulation (Device)
Sequence 3 - Training (same task) - Short follow-up
Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Paired Associative Stimulation (Device)
Sequence 3 - Training (same task) - Short follow-up
Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Cervicomedullar stimulation (Device)
Sequence 3 - Training (same task) - Short follow-up
Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Mental training (Other)
Sequence 3 - Training (different task) - Long follow-up
Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Transcranial magnetic stimulation (Device)
Sequence 3 - Training (different task) - Long follow-up
Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Peripheral Nerve Stimulation (Device)
Sequence 3 - Training (different task) - Long follow-up
Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Paired Associative Stimulation (Device)
Sequence 3 - Training (different task) - Long follow-up
Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Cervicomedullar stimulation (Device)
Sequence 3 - Training (different task) - Long follow-up
Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Mental training (Other)
Sequence 3 - Training (different task) - Short follow-up
Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Transcranial magnetic stimulation (Device)
Sequence 3 - Training (different task) - Short follow-up
Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Peripheral Nerve Stimulation (Device)
Sequence 3 - Training (different task) - Short follow-up
Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Paired Associative Stimulation (Device)
Sequence 3 - Training (different task) - Short follow-up
Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Cervicomedullar stimulation (Device)
Sequence 3 - Training (different task) - Short follow-up
Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Mental training (Other)
Sequence 3 - Control 1
Mental Training Motor task (same as the motor task) Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Transcranial magnetic stimulation (Device)
Sequence 3 - Control 1
Mental Training Motor task (same as the motor task) Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Peripheral Nerve Stimulation (Device)
Sequence 3 - Control 1
Mental Training Motor task (same as the motor task) Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Cervicomedullar stimulation (Device)
Sequence 3 - Control 1
Mental Training Motor task (same as the motor task) Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Mental training (Other)
Sequence 3 - Control 2
Paired Associative Stimulation Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Transcranial magnetic stimulation (Device)
Sequence 3 - Control 2
Paired Associative Stimulation Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Peripheral Nerve Stimulation (Device)
Sequence 3 - Control 2
Paired Associative Stimulation Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Paired Associative Stimulation (Device)
Sequence 3 - Control 2
Paired Associative Stimulation Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
干预措施: Cervicomedullar stimulation (Device)
Sequence 4 - Immobilization - Short follow-up
Transcranial magnetic stimulation Arm immobilization Motor task Mental training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 4 - Immobilization - Short follow-up
Transcranial magnetic stimulation Arm immobilization Motor task Mental training
干预措施: Wrist (Device)
Sequence 4 - Immobilization - Short follow-up
Transcranial magnetic stimulation Arm immobilization Motor task Mental training
干预措施: Mental training (Other)
Sequence 4 - Immobilization - Long follow-up
Transcranial magnetic stimulation Arm immobilization Motor task Mental training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 4 - Immobilization - Long follow-up
Transcranial magnetic stimulation Arm immobilization Motor task Mental training
干预措施: Wrist (Device)
Sequence 4 - Immobilization - Long follow-up
Transcranial magnetic stimulation Arm immobilization Motor task Mental training
干预措施: Mental training (Other)
Sequence 4 - Cathodal - Short follow-up
Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 4 - Cathodal - Short follow-up
Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training
干预措施: Transcranial direct current stimulation (Device)
Sequence 4 - Cathodal - Short follow-up
Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training
干预措施: Mental training (Other)
Sequence 4 - Cathodal - Long follow-up
Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 4 - Cathodal - Long follow-up
Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training
干预措施: Transcranial direct current stimulation (Device)
Sequence 4 - Cathodal - Long follow-up
Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training
干预措施: Mental training (Other)
Sequence 4 - Anodal - Short follow-up
Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 4 - Anodal - Short follow-up
Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training
干预措施: Transcranial direct current stimulation (Device)
Sequence 4 - Anodal - Short follow-up
Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training
干预措施: Mental training (Other)
Sequence 4 - Anodal - Long follow-up
Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training
干预措施: Transcranial magnetic stimulation (Device)
Sequence 4 - Anodal - Long follow-up
Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training
干预措施: Transcranial direct current stimulation (Device)
结局指标
主要结局
Evolution of movement accuracy - Sequence 1
时间窗: Each day in Sequence 1 (Sequence 1 is 11 days)
The accuracy of performed movement sequences (i.e., the correspondence between the performed finger motor sequences and the requested finger motor sequence).
Evolution of maximal deviation - Sequence 2
时间窗: Each day in Sequence 2 (Sequence 1 is 10 days)
The maximal perpendicular distance between the position of the hand and the straight line joining the starting target and the final target
Evolution of movement speed - Sequence 1
时间窗: Each day in Sequence 1 (Sequence 1 is 11 days)
The duration of performed movement sequences
Evolution of trajectory error - Sequence 2
时间窗: Each day in Sequence 2 (Sequence 1 is 10 days)
The area under the curve of hand's trajectory according to the straight line joining the starting target and the final target.
Evolution of final error - Sequence 2
时间窗: Each day in Sequence 2 (Sequence 1 is 10 days)
The distance between the final position of the hand and the position of the final target.
Evolution of movement speed - Sequence 3
时间窗: Each day from day 2 to day 11 of Sequence 3 (Sequence 3 is 11 days)
The duration of performed movement sequences
Evolution of movement accuracy - Sequence 3
时间窗: Each day from day 2 to day 11 of Sequence 3 (Sequence 3 is 11 days)
The accuracy of performed movement sequences (i.e., the correspondence between the performed finger motor sequences and the requested finger motor sequence).
Evolution of movement speed - Sequence 4
时间窗: Each day in Sequence 4 (Sequence 4 is 6 days)
The duration of performed movement sequences
Evolution of movement accuracy - Sequence 4
时间窗: Each day in Sequence 4 (Sequence 4 is 6 days)
The accuracy of performed movement sequences (i.e., the correspondence between the performed finger motor sequences and the requested finger motor sequence).
次要结局
- Evolution of motor evoked potentials amplitude - Sequence 2(Each day in Sequence 2 (Sequence 2 is 10 days))
- Evolution of motor evoked potentials amplitude - Sequence 1(Day 1, 5, 6, 10 and 11 in Sequence 1 (Sequence 1 is 11 days).)
- Evolution of motor evoked potentials amplitude - Sequence 4(Days 1, 5, and 6 in Sequence 4 (Sequence 4 is 6 days))
- Evolution of motor evoked potentials amplitude - Sequence 3(Day 1, 5, 6, 10 and 11 in Sequence 3 (Sequence 1 is 11 days))