Investigation of the Neurophysiological and Psychological Aspects of Itch
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Itch
- Sponsor
- Aalborg University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Numeric rating scales (NRS)
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The aim of this project is to determine the effects of performing a motor imagery task on cortical excitability during acute experimental muscle pain (induced by hypertonic saline), acute histaminergic itch (induced by histamine), and non-histaminergic itch stimulation (triggered by Cowhage). We hypothesize that motor imagery will counteract the alterations in cortical excitability observed during experimental muscle pain and both itch models.
Detailed Description
Itch and pain share many similarities and dissimilarities in terms of the mechanisms and molecules involved. Many studies have been conducted to explain all the neurophysiological aspects involved in the pain process, and cortical adaptations have been provoked in healthy individuals using experimental pain models. Unfortunately, all these aspects still need to be clarified regarding itch. Has been previously demonstrated that motor imagery can counteracted the pain-induced decrease in corticospinal excitability observed during acute pain, and it has also been proposed as a potential intervention for individuals with pain to restore maladaptive neuroplasticity. However, whether motor imagery can similarly counteract the itch-induced cortical changes remains unclear. Therefore, the aim of this project is to investigate whether motor imagery would counteract the reduction in cortical excitability during acute itch, similar to the effects observed in the context of acute pain.
Investigators
Silvia Lo Vecchio
Associate Professor
Aalborg University
Eligibility Criteria
Inclusion Criteria
- •Healthy men and women
- •18-60 years
- •Speak and understand English
Exclusion Criteria
- •Pregnancy or lactation
- •Drug addiction defined as any use of cannabis, opioids, or other addictive drugs
- •Previous or current history of neurological (e.g. neuropathy), immunological (e.g. asthma, immune deficiencies, arthritis), musculoskeletal (e.g. muscular pain in the upper extremities,), cardiac disorder (e.g., heart stroke), or psychiatric diagnoses (e.g. depression) that may affect the results
- •Current use of medications that may affect the trial, such as antihistamines, antipsychotics, and painkillers, as well as systemic or topical steroids
- •Skin diseases (e.g., atopic dermatitis, pruritus nodularis, eczema, psoriasis)
- •Moles, scars, or tattoos in the area to be treated or tested.
- •Consumption of alcohol or painkillers 24 hours before the study days and between these
- •Acute or chronic pain
- •Unable to pass the "Transcranial Magnetic Stimulation Adult Safety Screen" (subproject 1 and 2)
- •Contraindications to transcranial magnetic stimulation (TMS) application (history of epilepsy, metal implants in head or jaw, etc.)
Outcomes
Primary Outcomes
Numeric rating scales (NRS)
Time Frame: 1 minute after every itch/pain induction
NRS are essentially VAS but have tick marks spaced every centimeter so as to create 11-point scale (from 0 to 10). Subject can use these tick marks as a guide when they mark their severity on the scale.
Measuring cortical excitability (TEPs)
Time Frame: Post induction of itch or pain
Transcranial magnetic stimulation (TMS) with a figure-eight-shaped cone coil will be used to evoke cortical responses in the motor cortex. The resulting TMS-evoked potentials (TEPs) will be collected using an electroencephalogram (EEG). Similar to the baseline, this assessment will last for 7 minutes after itch or pain.
Secondary Outcomes
- Pain Catastrophizing Scale (PCS).(Baseline)
- Reinforcement Sensitivity Theory - Personality Questionnaire (RST-PQ).(Baseline)
- The Pittsburg Sleep Quality Index (PSQI)(Baseline)
- Learned Helplessness Scale (LHS)(Baseline)
- Itch Catastrophizing Scale (ICS).(Baseline)
- Depression, Anxiety, Stress Scale (DASS-21)(Baseline)
- Positive And Negative Affect Schedule (PANAS)(Baseline)