Local Haemodynamic Effects of Apelin Agonists and Antagonists in Man in Vivo
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- Forearm blood flow measured by forearm plethysmography in response to infused vasodilators
研究概览
简要总结
Apelins are substances which occur naturally in the body, and have an important role in heart disease. They have been shown to make blood vessels dilate, and improve the way the heart works.
The investigators have devised 2 sets of experiments to investigate how the apelins affect blood vessels.
In the first group of experiments,the investigators will give healthy volunteers up to 3 different apelin substances, and use special research techniques to see how they affect the way that blood vessels work in the forearm.
In the second group of experiments, the apelins will be given along with another form of apelin which blocks the effects of apelin in laboratory experiments. The investigators want to see if it blocks the effects of apelin in healthy humans.
The investigators intend to test the hypothesis that:
Apelin agonists are vasodilators in human resistance vessels, this effect will be blocked by an apelin receptor antagonist.
This study will help us to understand more about how apelins work, and to suggest how they might be used to treat heart disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Between 18 and 70 years
- •Non-regular smoking (<5 cigarettes per week)
- •If female, postmenopausal or on days 2-9 of menstrual cycle
排除标准
- •Hypertension (sustained BP >160/100mmHg)
- •Ischaemic Heart Disease
- •Renal, respiratory or neurological disease
- •Diabetes mellitus
- •BMI >30, BMI <18
- •Use of vasoactive medication or NSAIDS/aspirin within 48 hours of study.
- •Current involvement in other research studies
研究组 & 干预措施
Apelin agonist infusion
Studies to measure change in blood flow in response to apelin agonists (1/10/100nmol) using forearm venous occlusion plethysmography and Aellig hand vein technique.
干预措施: Forearm venous occlusion plethysmography (Procedure)
Apelin agonist infusion
Studies to measure change in blood flow in response to apelin agonists (1/10/100nmol) using forearm venous occlusion plethysmography and Aellig hand vein technique.
干预措施: Aellig hand vein technique (Procedure)
Apelin agonist infusion
Studies to measure change in blood flow in response to apelin agonists (1/10/100nmol) using forearm venous occlusion plethysmography and Aellig hand vein technique.
干预措施: Apelin agonist infusion (Other)
Apelin receptor antagonist infusion
Aellig hand vein technique will be used to investigate the change in vein diameter in response to an apelin blocking agent
干预措施: Aellig hand vein technique (Procedure)
Apelin receptor antagonist infusion
Aellig hand vein technique will be used to investigate the change in vein diameter in response to an apelin blocking agent
干预措施: Apelin receptor antagonist infusion (Other)
Apelin agonist/antagonist co-infusion
Forearm blood flow study to measure blood flow by forearm venous occlusion plethysmography following intraarterial infusion of apelin receptor agonists and antagonist.
干预措施: Forearm venous occlusion plethysmography (Procedure)
Apelin agonist/antagonist co-infusion
Forearm blood flow study to measure blood flow by forearm venous occlusion plethysmography following intraarterial infusion of apelin receptor agonists and antagonist.
干预措施: Apelin agonist infusion (Other)
Apelin agonist/antagonist co-infusion
Forearm blood flow study to measure blood flow by forearm venous occlusion plethysmography following intraarterial infusion of apelin receptor agonists and antagonist.
干预措施: Apelin receptor antagonist infusion (Other)
结局指标
主要结局
Forearm blood flow measured by forearm plethysmography in response to infused vasodilators
时间窗: 2-3 hours
Change in hand vein diameter measured by Aellig hand vein technique, in response to study peptides
时间窗: 2-3 hours
次要结局
未报告次要终点
研究者
Dr Aimee Brame MRCP
Research Fellow
University of Cambridge