Interaction of Apelin and Angiotensin in the Systemic Circulation

Not Applicable

Completed

• Conditions: Renin Angiotensin System
• Interventions: Drug: Angiotensin II; Drug: Saline

• Registration Number: NCT01049646
• Lead Sponsor: University of Edinburgh

Brief Summary

The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease.

Apelin improves that pumping ability of the heart and we wish to know if this action persists in the presence of increased levels of angiotensin II.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01
• Study First Submitted: 2010-01-13
• Study First Submitted QC: 2010-01-13
• Study First Posted: 2010-01-14
• Primary Completion: 2010-04
• Study Completion: 2010-04
• Status Verified: 2010-08
• Last Update Submitted: 2010-08-09
• Last Update Posted: 2010-08-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 12

Inclusion Criteria

• > 18 years old
• Healthy volunteers

Exclusion Criteria

• Lack of informed consent
• Age < 18 years,
• Current involvement in other research studies,
• Systolic blood pressure >190 mmHg or <100 mmHg
• Malignant arrhythmias
• Renal or hepatic failure
• Haemodynamically significant aortic stenosis
• Severe or significant co morbidity
• Women of childbearing potential.

Any regular medication

• Previous history of any cardiovascular disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Angiotensin II	Angiotensin II	-
Saline infusion	Saline	-

Primary Outcome Measures

Name	Time	Method
Cardiac output	90 mins

Secondary Outcome Measures

Name	Time	Method
Systemic haemodynamics	90mins

Trial Locations

Locations (1)

Clincial Research Facility, Royal Infirmary of Edinburgh, 51 Little France Cresc; 🇬🇧 Edinburgh, United Kingdom