Interaction of Apelin and Angiotensin in the Systemic Circulation
Not Applicable
Completed
- Conditions
- Renin Angiotensin System
- Interventions
- Drug: Saline
- Registration Number
- NCT01049646
- Lead Sponsor
- University of Edinburgh
- Brief Summary
The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease.
Apelin improves that pumping ability of the heart and we wish to know if this action persists in the presence of increased levels of angiotensin II.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 12
Inclusion Criteria
- > 18 years old
- Healthy volunteers
Exclusion Criteria
- Lack of informed consent
- Age < 18 years,
- Current involvement in other research studies,
- Systolic blood pressure >190 mmHg or <100 mmHg
- Malignant arrhythmias
- Renal or hepatic failure
- Haemodynamically significant aortic stenosis
- Severe or significant co morbidity
- Women of childbearing potential.
Any regular medication
- Previous history of any cardiovascular disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Angiotensin II Angiotensin II - Saline infusion Saline -
- Primary Outcome Measures
Name Time Method Cardiac output 90 mins
- Secondary Outcome Measures
Name Time Method Systemic haemodynamics 90mins
Trial Locations
- Locations (1)
Clincial Research Facility, Royal Infirmary of Edinburgh, 51 Little France Cresc
🇬🇧Edinburgh, United Kingdom
Clincial Research Facility, Royal Infirmary of Edinburgh, 51 Little France Cresc🇬🇧Edinburgh, United Kingdom