Investigating the Interaction of Apelin and Angiotensin II Peripheral Resistance Vessels in Vivo in Man
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Change in angiotensin II mediated vasoconstriction
研究概览
简要总结
The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease.
Apelin has the ability to cause blood vessels to relax, increasing their diameter and hence blood flow down the blood vessel. The researchers wish to investigate the hypothesis that an infusion of apelin will reduce the effects of angiotensin II, which is know to reduce the diameter of blood vessels.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •> 18 years old
- •Healthy volunteers
排除标准
- •Lack of informed consent
- •Age < 18 years,
- •Current involvement in other research studies,
- •Systolic blood pressure >190 mmHg or <100 mmHg
- •Malignant arrhythmias
- •Renal or hepatic failure
- •Haemodynamically significant aortic stenosis
- •Severe or significant co morbidity
- •Women of childbearing potential.
- •Any regular medication
- •Previous history of any cardiovascular disease
研究组 & 干预措施
Infusion of apelin
Using forearm venous occlusion plethysmography apelin will be infused to cause reduction in forearm blood flow. Infusion of angiotensin II and noradrenaline will given and vasoconstriction will be assessed. Blood samples for the infused arm and contra-lateral arm will be taken at regular time points to assess local and systemic changes in relevant hormones.
干预措施: Angiotensin II (Drug)
Infusion of apelin
Using forearm venous occlusion plethysmography apelin will be infused to cause reduction in forearm blood flow. Infusion of angiotensin II and noradrenaline will given and vasoconstriction will be assessed. Blood samples for the infused arm and contra-lateral arm will be taken at regular time points to assess local and systemic changes in relevant hormones.
干预措施: Noradrenaline infusion (Drug)
Sodium nitroprusside infusion
Using forearm venous occlusion plethysmography sodium nitroprusside will be infused to cause reduction in forearm blood flow. Infusion of angiotensin II and noradrenaline will given and vasoconstriction will be assessed. Blood samples for the infused arm and contra-lateral arm will be taken at regular time points to assess local and systemic changes in relevant hormones.
干预措施: Angiotensin II (Drug)
Sodium nitroprusside infusion
Using forearm venous occlusion plethysmography sodium nitroprusside will be infused to cause reduction in forearm blood flow. Infusion of angiotensin II and noradrenaline will given and vasoconstriction will be assessed. Blood samples for the infused arm and contra-lateral arm will be taken at regular time points to assess local and systemic changes in relevant hormones.
干预措施: Noradrenaline infusion (Drug)
结局指标
主要结局
Change in angiotensin II mediated vasoconstriction
时间窗: 12 months
次要结局
- Changes in relevant neurohumoral hormones in response to apelin infusion(12 months)