Effects of Rehydration During Physical Exercise on Acute Kidney Injury Biomarkers
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Change in urinary AKI biomarkers (urianry NGAL, urinary KIM -1, urinary cystatin-C) after physical exercise
研究概览
简要总结
Rehydration during and after physical exercise is essential to avoid acute kidney injury.
Soft drinks are commonly used during exercise. High intake of carbohydrates is leading to obesity and metabolic disorders. Fructose intake is leading to uric acid abnormalities and kidney injury.
30 healthy soccer players will be studied. During four training sessions subjects will intake 500 ml 7% soft drinks containing glucose, fructose, saccharose or xylitol.
Changes in acute kidney injury markers, markers of kidney tubular function as well as changes in CRP, glucose, cholesterol and uric acid levels will be studied..
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Diagnostic
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age above 18 years
- •well-trained soccer players
- •informed consent
排除标准
- •chronic diseases, especially kidney problems
- •sigificant changes in urinalysis
- •creatinine level above normal values
结局指标
主要结局
Change in urinary AKI biomarkers (urianry NGAL, urinary KIM -1, urinary cystatin-C) after physical exercise
时间窗: after 60-90 min of pysical exercise
Changes in fractional uric acid excretion
时间窗: after 60-90 min of pysical exercise
次要结局
未报告次要终点
研究者
Wojciech Wolyniec
Principal Investigator
Medical University of Gdansk