Comparison of endothelial function with the mandibular advancement device (MAD) versus continuous positive airway pressure (CPAP) among patients with moderate sleep apnea syndrome: multicenter, open label, prospective randomized non-inferiority crossover trial
Not Applicable
- Conditions
- Sleep apnea syndrome
- Registration Number
- JPRN-UMIN000014723
- Lead Sponsor
- Sleep apnea center,Kyushu university hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
1. History of treatment of OSAS 2. Patients who needs to treat immediately 3. With central sleep apnea dominance (CAHI>5) 4. With insomnia or hypersomnia not relate to OSAS 5. Using sedatives, 6. With pulmonary (asthma, COPD etc.) or mental disease which needs to treat 7. Unable to fit MAD 8. With coronary heart disease and cerebrovascular disease 9. On hemodialysis 10. Patients who are judged unsuitable to participate in the study by the attending physician
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The degree of change in FMD at the end of each course of therapy
- Secondary Outcome Measures
Name Time Method