Effects of Temporary Inhibition of the Renin-Angiotensin System on future blood pressure and hypertensive organ damage in young prehypertensive adults - TIResiAS.
- Conditions
- Prehypertension, defined as an avarage office blood pressure of 130-139/85-89 mmHg.
- Registration Number
- NL-OMON22745
- Lead Sponsor
- Academic Medical Centre Dept.Vascular Medicine Meibergdreef 9 1105 AZ Amsterdam The Netherlands Tel +31 20 5669111
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 300
Inclusion Criteria
Otherwise healthy persons aged 18-40 years with 3 cardiovascular risk factors or less and an average blood pressure of 130-139 systolic/below 90 mmHg diastolic and/or below 130 systolic/ 85-89 mmHg diastolic on 2 separate visits with an interval of 1 week and measured by a validated automatic blood pressure device.
Exclusion Criteria
1. Previous antihypertensive treatment;
2. Any chronic use of prescribed oral medication except oral contraceptives;
3. An elevated baseline serum glucose (>7.0 mmol/L) or elevated serum creatinine(> 95 ummol/L for women and >110 ummol/L for men);
4. Women with a wish to become pregnant in the treatment period.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differences in ambulatory blood pressure between lisinopril and placebo 2 years after cessation of active treatment compared to baseline.
- Secondary Outcome Measures
Name Time Method Differences in left ventricular mass (index) and microalbuminuria between lisinopril and placebo 2 years after cessation of active treatment compared to baseline.