Effects of Temporary Inhibition of the Renin-Angiotensin System on future blood pressure and hypertensive organ damage in young prehypertensive adults

Not Applicable

Completed

• Conditions: Prehypertension; Circulatory System; Hypertension

• Registration Number: ISRCTN52222985
• Lead Sponsor: Academic Medical Centre (AMC) (The Netherlands)

Brief Summary

2007 results in https://pubmed.ncbi.nlm.nih.gov/17822254/ (added 26/03/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-02-26
• Study Completion: 2011-02-01
• Last Update Posted: 12 April 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 300

Inclusion Criteria

Otherwise healthy persons aged 18 to 40 years with three cardiovascular risk factors or less and an average blood pressure of 130 - 139 systolic/below 90 mmHg diastolic and/or below 130 systolic/ 85 - 89 mmHg diastolic on two separate visits with an interval of one week and measured by a validated automatic blood pressure device.

Exclusion Criteria

1. Previous antihypertensive treatment
2. Any chronic use of prescribed oral medication except oral contraceptives
3. An elevated baseline serum glucose (more than 7.0 mmol/L) or elevated serum creatinine(more than 95 ummol/L for women and more than 110 ummol/L for men)
4. Women with a wish to become pregnant in the treatment period

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Differences in ambulatory blood pressure between lisinopril and placebo two years after cessation of active treatment compared to baseline.

Secondary Outcome Measures

Name	Time	Method
Differences in left ventricular mass (index) and microalbuminuria between lisinopril and placebo two years after cessation of active treatment compared to baseline.