Evaluation of Renal Damage After PCNL and ESWL Using Novel RNA Based Biomarkers
试验速览
- 阶段
- 不适用
- 入组人数
- 75
- 试验地点
- 2
- 主要终点
- Evaluation of renal damage after PCNL and ESWL using novel RNA based Biomarkers
研究概览
简要总结
The study evaluate the damage effect of ESWL and PCNL on kidney tissue by measuring non-coding lnc-RNA profile in urine before and after ESWL and PCNL procedures
详细描述
The study evaluate the damage effect of ESWL and PCNL on kidney tissue by measuring non-coding lnc-RNA profile in urine before and after ESWL and PCNL procedures and assess their usefulness as diagnostic biomarkers for AKI and the relationship between the selected RNA based biomarker panel and clinicopathological changes of patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Inclusion criteria for patients :
- •Patients undergoing treatment for a stone(s) located in the kidney less than 2 cm
- •Radiopaque stone
- •Able and willing to give informed consent
- •Inclusion criteria for Healthy volunteers
- •No history of kidney or stone disease
- •Asymptomatic
- •No indwelling ureteral stent
- •Willing to provide medical history information
- •Able and willing to give informed consent
排除标准
- •Exclusion criteria for patients
- •Active urinary tract infection
- •Bleeding disorder
- •Chronic renal failure (eGFR<30)
- •Ureteral stone
结局指标
主要结局
Evaluation of renal damage after PCNL and ESWL using novel RNA based Biomarkers
时间窗: Before the procedure by 2hours and after the procedure by 2 and 24 hours
Evaluation of kidney injury after procedures PCNL and ESWL by measuring the change of the level of novel non-coding lnc-RNA profile in urine
次要结局
未报告次要终点