DEfective HUman SAlivary gland stem cells: the cause of Primary Sjögren*s syndrome? -DEHUSAPS study

Completed

• Conditions: Sjögren's disease; Sjögren's syndrome; 10003816

• Registration Number: NL-OMON43500
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2019-03-23
• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 93

Inclusion Criteria

• Presents with classic dry mouth symptoms presumed to be pSS.
• Willing to have exam of oral cavity.
• Scheduled for parotid biopsy for routine diagnosis and care.
• Scheduled for saliva collection for routine diagnosis and care (not in controls).

Exclusion Criteria

• History of radiation therapy to the head or neck.
• Another auto-immune disease, sarcoidosis, hepatitis C, IgG4 disease, HIV (all exclusion criteria for classifying a subject as pSS).

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To define pSS SGSC defects using self-renewal and organoid formation techniques<br /><br>on pSS-derived SGSCs.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Through comparison to healthy SGSCs, transcriptome and proteome screens will<br /><br>unveil key pSS SGSC defects. Relating potential pSS modulators to patient<br /><br>biopsy banks, and chemically and/or genetically interfering with their activity<br /><br>will validate our findings. </p><br>