Minor Salivary Gland Transplantation for Severe Dry Eye Disease

Not Applicable

• Conditions: Dry eye disease; Eye - Diseases / disorders of the eye

• Registration Number: ACTRN12611000832976
• Lead Sponsor: Dinesh Selva

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-08-08
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

All patients with severe DED defined by OSDI score and stage 4 dry eye severity grading scheme
Persistant severe pain and symptoms
Marked conjunctival staining
Severe corneal erosions
Flourescein tear break up time immediate (TBUT)
Schirmer score <2

Inclusion for healthy control group:
Clinically no evidence of dry eye disease
Able to attend the follow-up appointments

Exclusion Criteria

Age <18 years old
Pregnancy
Inability to provide consent
Previous gland graft
Existing ocular disease
Subjects using topical or systemic medications for allergies
Contact lens wearers
Smokers

Exclusion criteria for control group:
Pregnancy
Inability to provide consent
Existing ocular disease
Subjects using topical or systemic medications for allergies
Contact lens wearers
Smokers

Study & Design

• Study Type: Interventional
• Study Design: Not specified