Grading Scale of Vitreous Haze in Patients With Uveitis Using Ultrasonography

Not Applicable

Withdrawn

• Conditions: Uveitis
• Interventions: Device: Ultrasonography B-scan

• Registration Number: NCT02311192
• Lead Sponsor: University of Nebraska

Brief Summary

This study is aimed at creation and validation of a vitreous haze scoring system using ultrasonography B-scan of the eye. Images will be obtained from patients with uveitis and quantification of inflammation will be done to create the scoring scale.

Detailed Description

Patients with uveitis may present with Vitreous Haze (VH) resulting in obscuration of fundus details. VH is composed of cells and protein exudation and results in decrease visual acuity.The degree of VH is an important indicator of disease activity, severity and response to therapy in patients with uveitis. Color fundus images are commonly used to objectively document VH.

Study Timeline

• Study Start: 2014-10-01
• Study First Submitted: 2014-12-04
• Study First Submitted QC: 2014-12-05
• Study First Posted: 2014-12-08
• Primary Completion: 2016-09-30
• Study Completion: 2016-09-30
• Status Verified: 2023-08
• Last Update Submitted: 2023-08-11
• Last Update Posted: 2023-08-15

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• • Ability to provide written informed consent and comply with study assessments for the full duration of the study

  • Age 18 -90 years
  • Diagnosis of uveitis

Exclusion Criteria

• • Patients with posterior segment complications including retinal detachment, choroidal detachment or hemorrhage

  • Patients with any intraocular foreign body or displaced intraocular lens
  • Patients with silicon oil filled eye or with gas tamponade.
  • Patients with vitreous hemorrhage
  • Patients with media opacity including visually significant cataract that precludes grading of VH based on fundus photography

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Ultrasonography B-scan	Ultrasonography B-scan	Patients of uveitis who are included in the study will be imaged using ultrasound B-scan

Primary Outcome Measures

Name	Time	Method
Inter-observer correlation for vitreous haze grading	1 year	Inter-observer correlation for vitreous haze (VH) grading will be assessed using number of eyes as the unit of measure as well as standardized grading scheme for VH