Myocardial Injuries and Hemodynamic Stress Biomarkers: a Comparison Between Transvenous and Subcutaneous ICD Shock
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- ICD Shock Myocardial Injuries
- Sponsor
- Monaldi Hospital
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- myocardial micro-damage
- Last Updated
- 8 years ago
Overview
Brief Summary
Implantable cardioverter defibrillator (ICD) shocks are associated with a subsequent increased risk of death, and an elevation of cardiac enzymes has been measured after defibrillation testing (DFT). The aim of our study was to investigate the association between S-ICD vs T-ICD shocks and acute cardiac damage in humans, as evaluated by means of sensitive and highly specific circulating biomarkers
Investigators
Antonio D'Onofrio
MD, FESC
Monaldi Hospital
Eligibility Criteria
Inclusion Criteria
- •patients who met the criteria for ICD implantation according to the current guidelines
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
myocardial micro-damage
Time Frame: 6 months
degree of myocardial micro-damage, assessed by calculating the variation in the serum levels of high-sensitivity cardiac troponin I (hs-CTnI) and creatine kinase-MB mass concentration (CK-MB mass), measured before and after an S-ICD shock delivered during intraoperative DFT