Effect of Sodium Bicarbonate Buffered Lidocaine on the Success of Inferior Alveolar Nerve Block for Teeth With Symptomatic Irreversible Pulpitis: A Prospective, Randomized Double-blind Study
Overview
- Phase
- Phase 3
- Intervention
- sodium bicarbonate
- Conditions
- Local Anesthesia
- Sponsor
- Masoud Saatchi
- Enrollment
- 80
- Primary Endpoint
- Percentage of the success of IAN Block anesthesia with a buffered 2% lidocaine with 1:80,000 epinephrine solution for inferior alveolar nerve block
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Buffering of local anesthetics (alkalinization) has been suggested in achieving pain control. The purpose of this prospective, randomized, double-blind study was to evaluate the effect of adding 0.6 mL 8.4% sodium bicarbonate to 3.0 mL 2% lidocaine with 1: 80,000 epinephrine on the success rate of IAN block for endodontic treatment of mandibular molars with symptomatic irreversible pulpitis.
Detailed Description
Some studies have been shown buffering of local anesthetics reduce pain of injection, hasten the onset of anesthesia, and improved success rate of anesthesia. Others reported buffering of local anesthetics cannot reduce pain of injection, hasten the onset of anesthesia, and improve success rate of anesthesia. There are no studies evaluating a sodium bicarbonate-buffered lidocaine formulation for IAN block for teeth with irreversible pulpitis.
Investigators
Masoud Saatchi
associate professor
Isfahan University of Medical Sciences
Eligibility Criteria
Inclusion Criteria
- •vital mandibular molar tooth
- •diagnosis of symptomatic irreversible pulpitis
Exclusion Criteria
- •younger than 18 years old
- •history of significant medical conditions
- •allergies to local anesthetics or sulfites
- •pregnancy
- •taking any medications that might influence anesthetic assessment
- •active sites of pathosis in area of injection
- •inability to give informed consent
Arms & Interventions
lidocaine & sodium bicarbonate
2% lidocaine with 1: 80,000 epinephrine buffered with 0.18 mL of 8.4% sodium bicarbonate
Intervention: sodium bicarbonate
lidocaine & placebo
2% lidocaine with 1:80,000 epinephrine with 0.18 mL of sterile distilled water
Intervention: placebo
Outcomes
Primary Outcomes
Percentage of the success of IAN Block anesthesia with a buffered 2% lidocaine with 1:80,000 epinephrine solution for inferior alveolar nerve block
Time Frame: Baseline
Secondary Outcomes
- Heft-Parker visual analog scale recording of a non-buffered 2% lidocaine with 1:80,000 epinephrine solution for inferior alveolar nerve block(Baseline)