Prevalence of Aspirin Resistance in Chronic Kidney Disease Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- prevalence of aspirin resistance in chronic kidney disease patients
研究概览
简要总结
The primary objective of the study is to determine the prevalence of aspirin resistance in chronic kidney disease patients. The secondary objectives are to determine possible risk factors contributing to aspirin resistance in this population.
详细描述
A cross-sectional of "aspirin resistance in hemodialysis patients" previously done in our institution showed that 23/66 (34.7%) hemodialysis patients were aspirin resistant. In a recent systematic review, renal impairment was associated with aspirin resistance . This association was seen in only two out of the twenty studies used in this meta-analysis . Both these studies are from the same center with a predominant Asian population. In this study we will try to evaluate the prevalence of aspirin resistance in CKD patient without being limited to a specific ethnicity.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with known structural kidney disease as evident by history or by urinalysis and CKD stage III or IV determined by MDRD formula and who are taking aspirin.
排除标准
- •Younger than 18 years of age.
- •Bleeding disorder or myeloproliferative disorders.
- •Thrombocytopenia with platelets < 100.
- •Malignancy.
- •Acute hemorrhagic disease.
- •A recent history of receipt of platelet glycoprotein IIb/IIIa blockers.
- •Liver disease as evident by abnormal liver function and total bilirubin > 2mg/dl.
- •use of anticoagulation.
结局指标
主要结局
prevalence of aspirin resistance in chronic kidney disease patients
时间窗: 2 years
Blood drawn for the Accumetric test
次要结局
- risk factors contributing to aspirin resistance in this population.(2 years)
研究者
Suzanne El-Sayegh
Nephrology Attending, Assoc. Chair of Medicine
Northwell Health