Citizen Action for Sustainable Dengue Control in Sub-Saharan Africa

Not Applicable

Completed

• Conditions: Dengue

• Registration Number: NCT06648603
• Lead Sponsor: Swiss Tropical & Public Health Institute

Brief Summary

This project focuses on addressing arboviral outbreaks in Ivory Coast by involving local communities in the sustainable control of Aedes mosquitoes, utilizing scientific advice and environmental interventions. It will evaluate the impact of a participatory strategy on decreasing mosquito populations and the risk of virus transmission, aiming to provide insights for policy development on disease prevention.

Detailed Description

This project targets the growing threat of Aedes mosquito-borne diseases such as dengue in Africa, focusing on the Anono and Gbagba communities in Abidjan, Ivory Coast, by transitioning from traditional control approaches to a community-driven strategy. It focuses on educating and involving communities in the design of sustainable mosquito management measures, such as breeding site eradication and adult mosquito capturing, with scientific experts guiding the efforts. The approach will entail conducting sociocultural surveys and interactive workshops while also encouraging local participation and multi-sectoral collaboration. A randomized controlled trial (RCT) will test this effectiveness of this novel integrated community-based participatory intervention approach in reducing the transmission of Aedes mosquito and other arboviruses. This effort seeks to develop a scalable model for arboviral disease control, promote community resilience, and inform policy recommendations for better public health outcomes in resource-constrained urban settings.

Study Timeline

• Study Start: 2023-07-15
• Status Verified: 2023-12
• Study First Submitted: 2024-07-01
• Primary Completion: 2024-07-31
• Study Completion: 2024-09-30
• Study First Submitted QC: 2024-10-16
• Study First Posted: 2024-10-18
• Last Update Submitted: 2024-10-21
• Last Update Posted: 2024-10-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Not provided

Exclusion Criteria

1. Outside of trial clusters: households located outside the designated clusters in the two districts were excluded.
2. Refusal to participate: households that do not consent to mosquito trap placement or surveys
3. Inaccessibility: households that are not accessible for regular visits or data collection (e.g., due to relocation or difficult terrain).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Primary Outcome Measures

Name	Time	Method
Aedes aegypti mean number per trap per day	Continuously during months 1-4 (baseline) and months 5-17 (trial)	Biting rate is the mean number of Aedes females per trap and per day. The proportion of unfed, fed, half-gravid and gravid females will be estimated.

Secondary Outcome Measures

Name	Time	Method
House index	Before (month 1), twice during (month 4, 8) and once at the end of the trial (month 12)	House index: proportion of houses with at least one larva
Pupal indices: pupae per person index, pupa index and pupae per hectare index	Before (month 1), twice during (month 4, 8) and once at the end of the trial (month 12)	Pupae per person index: number of pupae per person Pupa index: number of pupae per house Pupae per hectare index: number of pupae per ha
Adults: parity rate	Continuously during months 1-4 (baseline) and months 5-17 (trial)	The parity rate (PR) (proposition of parous females) will be calculated to estimate vector longevity.
Knowledge, attitudes, and practices on Dengue prevention among the population of Cocody-Bingerville	Before (month 1) the start of the trial and at the end of the trial (month 12)	A Knowledge, Attitudes, and Practices (KAP) study will be conducted to assess the communities' understanding, attitudes, practices, and beliefs related to dengue. This will be done using a structured questionnaire developed specifically for this trial. The questionnaire comprises both multiple-choice and open-ended questions, allowing for a comprehensive assessment of: 1) Knowledge: Understanding of dengue transmission, symptoms, and prevention, 2) Attitudes: Perceptions of dengue risk and confidence in prevention methods, 3) Practices: Reported behaviors to prevent dengue, such as mosquito control measures. This structured tool will be used at both baseline and endline to measure changes and assess the effectiveness of the intervention."
Mapping and describe Aedes aegypti breeding sites, focusing on their geographic and ecological characteristics. This mapping will be used to enhance targeted larval control efforts in these areas.	Before (month 1) the start of the trial and at the end of the trial (month 12)	The geographic survey will collect household and environmental data, including demographic details, public space quality, water provision, sanitation access, and waste management practices. It will map housing conditions, examining building types, construction materials, and key features like water storage and solid waste management. The survey will also assess local built environments to inform interventions for improving living conditions and controlling mosquito breeding sites.
Container index	before (month 1), twice during (month 4, 8) and once at the end of the trial (month 12)	Proportion of positive containers
Breteau index	Before (month 1), twice during (month 4, 8) and once at the end of the trial (month 12)	Number of positive containers per 100 houses

Trial Locations

Locations (1)

Centre Suisse de Recherches Scientifiques en Côte d'Ivoire; 🇨🇮 Abidjan, Côte D'Ivoire